PO-HAN LINYeh M.-H.Liu L.-C.Chen C.-J.Tsui Y.-C.Su C.-H.Wang H.-C.Liang J.-A.Chang H.-W.Wu H.-S.Yeh S.-P.Li L.-Y.Chiu C.-F.2022-03-102022-03-1020130022-4790https://www.scopus.com/inward/record.uri?eid=2-s2.0-84886773504&doi=10.1002%2fjso.23403&partnerID=40&md5=865e57cad1a8587c8e4f04b33805f605https://scholars.lib.ntu.edu.tw/handle/123456789/596933Background and Objectives Patients with node-negative breast cancer (NNBC) usually have a good prognosis, but tumor recurrence still compromises survival. In this study, we sought to identify clinical and pathologic factors that predict recurrence. Methods A total of 716 patients who were proved with pT1-2N0M0 breast cancer between 2005 and 2009 were enrolled in this study. Results Forty-seven of the 716 patients developed tumor recurrence during the 47.0 months of median follow-up. The significant risk factors of recurrence were lymphovascular invasion (LVI) (hazard ratio [HR] = 4.60, 95% CI. 2.32-9.10) and Nottingham grade 3 (HR = 4.99, 95% CI. 1.06-23.48); adjuvant radiotherapy (HR = 0.35, 95% CI. 0.14-0.92) prevented tumor recurrence. Furthermore, we investigate the therapeutic impact of adjuvant chemotherapy and radiotherapy on patients with LVI and Nottingham grade 3. The adverse effect of LVI and grade 3 can be abrogated by adjuvant radiotherapy in recurrence-free survival (RFS) (LVI(+)radiotherapy(+), no recurrence; grade 3 (+)radiotherapy(+), HR = 0.82, 95% CI. 0.18-3.70). However, adjuvant chemotherapy did not. Conclusions LVI and Nottingham grade 3 were the independent risk factors predicting tumor recurrence for patients with NNBC. Adjuvant radiotherapy might be considered in NNBC patients with these unfavorable factors to improve the RFS. J. Surg. Oncol. 2013; 108:352-357. ? 2013 Wiley Periodicals, Inc. ? 2013 Wiley Periodicals, Inc.breast cancer; grade; lymphovascular invasion; node-negative; radiotherapy[SDGs]SDG3antineoplastic agent; adjuvant chemotherapy; adult; aged; article; breast cancer; cancer grading; cancer radiotherapy; confidence interval; female; follow up; hazard ratio; human; lymph vessel metastasis; major clinical study; mastectomy; node negative breast cancer; priority journal; recurrence free survival; risk factor; tumor recurrence; breast cancer; grade; lymphovascular invasion; node-negative; radiotherapy; Adult; Aged; Breast Neoplasms; Disease-Free Survival; Female; Humans; Kaplan-Meier Estimate; Lymph Nodes; Mastectomy, Modified Radical; Middle Aged; Neoplasm Grading; Neoplasm Recurrence, Local; Neoplasm Staging; Odds Ratio; Proportional Hazards Models; Radiotherapy, Adjuvant; Receptor, erbB-2; Retrospective Studies; Risk Assessment; Risk Factors; Triple Negative Breast Neoplasms; Tumor Markers, Biologicaljournal article10.1002/jso.23403239965832-s2.0-84886773504