Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction

CHANG-MU CHENChung, Yao-PangYao-PangChungLiu, Chia-HungChia-HungLiuHuang, Kuo-TongKuo-TongHuangGuan, Siao-SyunSiao-SyunGuanCHIH-KANG CHIANGWu, Chen-TienChen-TienWuSHING-HWA LIU2021-05-192021-05-192020-1209447113https://scholars.lib.ntu.edu.tw/handle/123456789/561408Withaferin A is a functional ingredient of a traditional medicinal plant, Withania somnifera, which has been broadly used in India for protecting against chronic diseases. This bioactive steroidal lactone possesses multiple functions such as anti-oxidation, anti-inflammation, and immunomodulation. Chronic kidney disease (CKD) is one of the major health problems worldwide with the high complication, morbidity, and mortality rates. The detailed effects and underlying mechanisms of withaferin A on CKD progression still remain to be clarified.enApoptosis; Chronic kidney disease; ER stress; Inflammation; Withaferin AWithaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstructionjournal article10.1016/j.phymed.2020.153352330077322-s2.0-85091632733https://api.elsevier.com/content/abstract/scopus_id/85091632733