2011-05-012024-05-13https://scholars.lib.ntu.edu.tw/handle/123456789/646018摘要：背景：適當的時間處理對於各種目標行為的引導、計畫、執行是相當重要的。過去有許多研究已針對時序（temporal order）知覺和時間長度（temporal duration）知覺的機制進行探討，但在時間不確定性（temporal uncertainty，一種在時間順序的表徵上呈現不規則性的情況）對於知覺影響的探討仍相當缺乏。此外，已有人提出時間知覺與特定頻率的神經震盪（neuronal oscillation，多個神經細胞依特定頻率共同活化造成的同步化現象，是建立不同神經細胞群間活化的時間關聯特性的重要機制）有著潛在的相關性。然而，臨床上特定族群其異常的時間處理與神經震盪的關聯至今仍不明。因此，本研究將針對此議題進行探討。目的：本研究計畫有兩大目的，第一：我們將探討時間不確定性對於視覺在時間和空間處理的影響。第二：將針對精神分裂症患者與泛自閉症患者其在時間處理的異常情形進行探討，藉此進一步了解異常的時間知覺處理與異常腦功能的關聯，以及其在臨床上的應用。本研究的三個主要目標為：目標1：在時間不確定的情境下，探討時序知覺的特性與機制。目標2：探討覺知移動中物體的空間位置與時間不確定性兩者交互作用的表徵與機制。目標3：探討精神分裂症與泛自閉症患者其時間處理的表徵，以及藉由時間假合錯覺（temporal aliasing illusion）實驗典範探討其表徵與異常神經震盪的潛在關聯。方法：在探討目標1與目標2時，將以心理物理學觀點與神經計算模型，探討視知覺在時間不確定情境下的心理物理特性，並且也從神經生理的觀點探討在時間不確定性下，其調控的神經機制。在探討目標3時，將利用一特殊的時間假合錯覺（temporal aliasing illusion）實驗典範與神經電生理學方法，探討精神分裂症與泛自閉症患者其異常時間處理背後的神經震盪頻率特性。預期結果：目標1與目標2將有助於我們了解時間不確定性對於視知覺影響的機制。目標3將為精神分裂症與泛自閉症患者，其認知獲知覺的異常和神經震盪之間的關聯提供一個新的觀點。綜觀而言，本研究計畫將有助於我們了解視覺對於時間處理的機制，以及其與精神疾患者神經震盪情形的關聯。<br> Abstract: Background: Correct temporal processing is critical to guide, plan and execute various goal-directed behaviors. Although most studies have been focused on the mechanisms underlying perception of time duration or temporal order judgment, much less is known about the influence of temporal uncertainty on our visual perception. On the other hand, there has been proposal that temporal processing can be linked partially to underlying neuronal oscillation at certain frequency bands. However, what may be the relationship between abnormal temporal processing and altered neuronal oscillation in some patient population is unclear. Therefore, the current proposal will aim to address these issues.Objectives: The general purposes of the current proposal are two-fold. First, we aim to investigate the interaction between spatial and temporal processing in the context of temporal uncertainty in vision. Second, we aim to investigate the characteristics of temporal processing in two clinical population, schizophrenia and ASD, with the goal to understand the relationship between abnormal temporal processing and abnormal brain function in these patients and the potential clinical implication. There are three specific aims: Aim 1) to investigate the characteristics and underlying mechanisms of temporal order perception in the context of temporal uncertainty; Aim 2) to investigate the characteristics and underlying mechanisms of interactions between perceived spatial location of a moving object and temporal uncertainty; Aim 3) to investigate the characteristics of temporal processing in Schizophrenia and autism spectrum disorders and its potential relationship with abnormal neuronal oscillation using temporal aliasing illusion paradigm.Method: For both Aim 1 and 2, we will use psychophysics combined with computational modeling approach to measure the psychophysics property of interaction between temporal uncertainty and visual perception, and use electrophysiological approach to investigate the underlying neuronal mechanisms of the modulation effects from temporal uncertainty. For Aim 3, we will use a specific type of temporal aliasing illusion paradigm combined with electrophysiological approach to investigate the frequency properties of neuronal oscillation underlying abnormal temporal processing in schizophrenics and autism spectrum disorders.Anticipated results: Results from Aim 1 and 2 will add to the existing literature by revealing the mechanisms about how temporal uncertainty may influence our visual perception. Results from Aim 3 will provide a new perspective to understand the relationship between certain cognitive deficits and abnormal neuronal oscillation in schizophrenics and autism spectrum disorders. The overarching results of the current proposal will contribute to the understanding of temporal processing in vision and its relationship with neuronal oscillation in psychiatric patient population.