Wu B.-R.Tsai M.-S.Yang C.-J.HSIN-YUN SUNLiu W.-C.Yang S.-P.Wu P.-Y.Su Y.-C.SUI-YUAN CHANGCHIEN-CHING HUNG2021-12-012021-12-0120141198-743Xhttps://www.scopus.com/inward/record.uri?eid=2-s2.0-84906790619&doi=10.1111%2f1469-0691.12504&partnerID=40&md5=222a98fc8e5a40a6b2f8ca61eef9d4b6https://scholars.lib.ntu.edu.tw/handle/123456789/588829Between 2009 and 2013, polymerase-chain-reaction assay was used to detect Treponema pallidum in the blood samples collected from 296 patients with early syphilis (241 being HIV infected) and 102 patients (34.5%) had spirochetemia. The presence of spirochetemia was associated with lower CD4 counts (per 10-cell/mm3 decrease, adjusted odds ratio (AOR), 1.020; 95% CI, 1.006-1.036) and secondary syphilis (AOR, 4.967; 95% CI, 2.016-12.238). Patients with early latent syphilis were less likely to achieve serological response compared with those with primary or secondary syphilis (AOR, 0.317; 95% CI, 0.142-0.708). However, serological response was not affected by presence of spirochetemia or antibiotic regimens. ? 2013 The Authors Clinical Microbiology and Infection ? 2013 European Society of Clinical Microbiology and Infectious Diseases.[SDGs]SDG3antibiotic agent; antiinfective agent; bacterial DNA; adult; antibiotic therapy; article; blood sampling; CD4 lymphocyte count; disease association; female; human; major clinical study; male; polymerase chain reaction; primary syphilis; priority journal; secondary syphilis; spirochete infection; spirochetemia; syphilis; treatment response; Treponema pallidum; treponematosis; bacteremia; blood; isolation and purification; prevalence; syphilis; Treponema pallidum; Spirochaetales; Treponema pallidum; Adult; Anti-Bacterial Agents; Bacteremia; CD4 Lymphocyte Count; DNA, Bacterial; Female; Humans; Male; Polymerase Chain Reaction; Prevalence; Syphilis; Treponema pallidumjournal article10.1111/1469-0691.12504243507852-s2.0-84906790619