黃慧璧Huang, Hui-Pi臺灣大學:獸醫學研究所汪士琬Wang, Shih-WanShih-WanWang2010-05-042018-07-092010-05-042018-07-092009U0001-0508200917061600http://ntur.lib.ntu.edu.tw//handle/246246/178928心臟生物指標（biomaker）主要可以分為兩大類，分別是結構性蛋白及功能性蛋白。其中最常被應用的結構性蛋白為心臟肌鈣蛋白I (cardiac troponin I)，負責測定各種造成心肌受損的疾病，是一種高敏感性及專一性的心臟生物指標。功能性蛋白N-terminal-pro B-type natriuretic peptide (NT-proBNP)是一種荷爾蒙，當細胞外液體過多造成心臟負擔時，心室壁會分泌此蛋白排出過多水分，維持體內正常循環。此論文包含兩個部份，第一部分研究心臟肌鈣蛋白I及NT-proBNP在健康及心臟瓣膜疾病之心衰竭患犬的血清濃度，第二部分研究治療前後心臟瓣膜疾病之心衰竭患犬心臟肌鈣蛋白I的濃度差異。研究結果指出心衰竭患犬血清的心臟肌鈣蛋白I及NT-proBNP濃度都明顯比健康犬高（分別為P=0.02, P<0.001），而且發現當心衰竭愈嚴重，血清中的心臟肌鈣蛋白I及NT-proBNP濃度愈高（分別為P=0.02, P<0.0001）。血清中心臟肌鈣蛋白I濃度，在治療後雖然明顯下降，但在統計結果並沒有顯著差異性存在（P=0.09）。根據此次的研究結果顯示測量血清中心臟肌鈣蛋白I及NT-proBNP濃度可以做為篩選是否罹患心臟疾病，並預測心衰竭嚴重程度。Biomarkers have been extensively used in human and veterinary medicine, and divided into two groups: the leakage markers and functional makers. Cardiac troponin I (cTnI), a structure protein of cardiomyocyte, is a sensitive, specific, is a leakage marker for cardiac injury. N-terminal-pro B-type natriuretic peptide (NT-proBNP), a hormone exerts a variety of effects of maintaining circulatory homeostasis in states of increased extracellular volume, is a functional maker. The thesis includes two sections: first part, association NT-proBNP and cTnI of clinically healthy dogs and dogs with heart failure (HF); second part, changes of cTnI concentrations before and after treatment for HF. The result of this study illustrated that concentrations of NT-proBNP and cTnI in the dogs with HF were higher than those in the control dogs (P<0.001, P=0.02, respectively), and these two cardiac makers were positively associated with severity of HF (P<0.0001, P=0.02, respectively). Serum cTnI concentrations decreased after treatment, but not reach significant different (P=0.09). Based on these findings, both cardia markers were able to identify presence of cardiac disease, and determine severity of HF in dogs.口試委員會審定書 icknowledgment iibstract iii文摘要 ivable of contents vist of Tables viist of Figures viihapter 1 General Introduction 1Reference 4hapter 2 Serum concentration of NT-proBNP and cardiac troponin I in determination of severity of canine heart failure caused by chronic degenerative mitral valvular disease8Reference 15hapter 3 Changes of serum cardiac troponin I concentrations before and after treatment for congestive heart failure caused by chronic degenerative mitral valvular disease in dogs22Reference 28hapter 4 General discussion and conclusion 37application/pdf455625 bytesapplication/pdfen-US心臟肌鈣蛋白I心臟瓣膜疾病心衰竭Cardiac Troponin IChronic Degenerative Valvular Diseasesheart failure[SDGs]SDG3thesishttp://ntur.lib.ntu.edu.tw/bitstream/246246/178928/1/ntu-98-R95629030-1.pdf