Chung C.-S.Tai C.-M.Huang T.-Y.Chang C.-W.Chen K.-C.Tseng C.-M.Wang H.-Y.Chu C.-H.Wu J.-M.Chen Y.HSIU-PO WANG2021-01-152021-01-1520180929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030634459&doi=10.1016%2fj.jfma.2017.09.003&partnerID=40&md5=7b1b82fc3cb89cfbc113a55959e62480https://scholars.lib.ntu.edu.tw/handle/123456789/540922Background/Purpose: Small bowel (SB) accounts for the majority of gastrointestinal tract but its tumors are rare and always overlooked. In this study, we aimed to evaluate the epidemiology of SB tumors. Methods: This multicenter retrospective study utilized endoscopy database from 2006/11 to 2016/07. Baseline demographic characteristics, clinical, radiologic and endoscopic findings were collected. Results: Totally 103 (34 benign, 69 malignant lesions) patients with SB tumors in 1070 enteroscopic examinations were enrolled. There were male preponderance (56.3% males, 43.7% females), both in benign (52.9%, 49.1%) and malignant (58.0%, 42.0%) lesions, except for subtype gastrointestinal stromal tumors (GISTs) (31.6%, 68.4%). The age (mean ± SD) at diagnosis in malignant SB tumors (62.2 ± 15.6) was older than those with benign tumors (50.7 ± 21.4) (p < 0.01). Bleeding (43.7%), abdominal pain (40.8%) and ileus (10.7%) were the most common clinical presentations. Hamartoma (32.4%) and adenoma (14.7%) were the most common benign histology. Four major malignant histological subtypes were lymphomas (29.0%), GISTs (27.5%), adenocarcinomas (26.1%) and metastatic cancers (14.5%). SB adenocarcinoma patients (>60-year-old, 77.8%) were older than lymphomas (60%) and GISTs (50%). Proximally location rates of lymphomas, GISTs, adenocarcinomas were 25.0% (5/20), 84.2% (16/19), and 88.9% (16/18), respectively. Conclusion: This endoscopy-based study revealed the most common histology of benign SB tumors were hamartoma and adenoma, and malignant ones were lymphomas, GISTs, adenocarcinomas and metastatic cancers. Most of them were male gender, except for GISTs, and with proximal location, except for lymphomas. Further large-scale investigation efforts are warranted to elucidate the epidemiology of SB tumors. ? 2017Enteroscopy; Small bowel; Small intestine; Tumors[SDGs]SDG3abdominal pain; adenoma; adolescent; adult; aged; Article; benign neoplasm; bleeding; child; chronic inflammation; computer assisted tomography; diarrhea; erosion; female; gastrointestinal stromal tumor; hamartoma; human; ileus; intestine endoscopy; lymphoma; major clinical study; male; nausea; push enteroscopy; retrospective study; small intestine cancer; small intestine tumor; Taiwan; vascular lesion; adenocarcinoma; age distribution; clinical trial; factual database; gastrointestinal endoscopy; gastrointestinal stromal tumor; intestine tumor; lymphoma; middle aged; multicenter study; pathology; sex ratio; small intestine; very elderly; young adult; Adenocarcinoma; Adolescent; Adult; Age Distribution; Aged; Aged, 80 and over; Child; Databases, Factual; Endoscopy, Gastrointestinal; Female; Gastrointestinal Stromal Tumors; Humans; Intestinal Neoplasms; Intestine, Small; Lymphoma; Male; Middle Aged; Retrospective Studies; Sex Distribution; Taiwan; Young Adultjournal article10.1016/j.jfma.2017.09.003289888882-s2.0-85030634459