內科CHIU, YUEH-HSIAYUEH-HSIACHIUWU, SHIAO-CHISHIAO-CHIWUTSENG, CHUEN-DENCHUEN-DENTSENGYEN, AMY MING-FANGAMY MING-FANGYENCHEN, TONY HSIU-HSITONY HSIU-HSICHEN陳秀熙2009-09-292018-07-112009-09-292018-07-112006http://ntur.lib.ntu.edu.tw//handle/246246/93097Objective: To investigate the prevalence and progression of, and identify risk factors for, pre-hypertension, stage 1 and 2 hypertension in a population-based study. Design: A prospective cohort study. Setting: An integrated community- based multiple screening program in Keelung, Taiwan. Participants: A total of 67 011 individuals aged 20-79 years between 1999 and 2003 were included. Of these, 22 111 reattended, yielding 53 689 repeated recordings of blood pressure, including movement between normal and prehypertension and progression from pre-hypertension to stage 1 or stage 2 hypertension. Main outcome measures: Blood pressure was defined and classified according to the JNC 7 Report as normal, prehypertension, stage 1, and stage 2 hypertension. Results: Below 50 years of age, males had a higher progression rate, particularly from normal to prehypertension , than females. Annual regression rates from pre-hypertension to normal were higher in the young age group than in the old age group, particularly for females. Factors associated with the occurrence of pre-hypertension were old age, male gender, high waist circumference, abnormal blood lipids , smoking, chewing betel nuts, lack of exercise, and having parents with hypertension. Factors associated with regression from pre-hypertension to normal were body mass index, fasting glucose, high-density lipoprotein level, smoking, and parents with hypertension. Progression from pre- hypertension to stage 1 hypertension was positively related to male gender , higher waist circumference, and having parents with hypertension. Conclusions: The rates of progression and regression of hypertension vary with age and gender, anthropometric and biochemical measurements, and family history. J Hypertens 24 :821 - 828 (c) 2006 Lippincott Williams & Wilkins.en-UShypertensionJNC 7 Reportmulti-state transitionpre- hypertensionjournal article