2003-08-012024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/710899摘要：大腦有多個記憶系統負責不同訊息的收錄、儲存與提取。各記憶系統彼此間的互動邇來深受重視。本研究計畫企圖透過研究杏仁核如何影響海馬來探討此一議題。杏仁核與情緒事件的記憶有關，海馬則負責記憶時空線索的複雜關係。杏仁核透過其輸出神經—終紋—影響其他區域的記憶的形成。終紋投射至中膈，從而可能改變中膈對海馬的乙醯膽鹼神經運作。證據顯示海馬乙醯膽鹼參與情境刺激的記憶歷程。因此事件的情緒成分，或是其所釋放的激素（如腎上腺素），有可能是透過杏仁核及終紋影響到海馬形成的情境記憶。潛伏學習是指受試者在沒有酬賞或懲罰的狀況下，會對情境刺激線索形成記憶。本三年期的計畫將利用不同作業的潛伏學習探討兩個記憶結構—杏仁核與海馬—如何共同促進情境記憶的形成。第一年的研究將企圖為抑制型逃避或其他學習作業建立一個穩定的潛伏學習模型，探討情緒壓力、腎上腺素及安非他命對情境記憶的影響，以及潛伏學習對海馬或其他神經結構間的依賴。第二年的研究將確立周邊腎上腺素促進潛伏學習的作用專一性與持久性，同時探討杏仁核以及其內的正腎上腺素在促進潛伏學習上的角色。第三年將探討周邊腎上腺素與杏仁核內腎上腺素對於潛伏學習的促進作用是否透過海馬進行，<br> Abstract: There are multiple memory systems in the brain. Interaction among these systems engaged by mnemonic demands of specific learning tasks has attracted much research attention. The present project intends to address this issue by studying how the amygdala may affect hippocampal memory functions. The amygdala is involved in memory of emotional events, while the hippocampus in spatial/contextual memory. The amygdala modulates memory formation elsewhere in the brain through its output in the stria terminalis (ST). By projecting to the lateral septum and activating intraseptal and septohippocampal fibers sequentially, the ST may modulate hippocampal cholinergic functions implicated in memory formation for contextual cues. Thus emotional stress or hormones thereby released (such as epinephrine) may modulate memory formation in the hippocampus through the amygdala and ST. The present project aims to study cooperation between the amygdala and hippocampus in facilitating memory formation in a latent learning paradigm, in which rats show incidental memory of context stimuli in a condition of not being reinforced. Studies in the first year aim to set up a latent learning paradigm in an inhibitory avoidance and other learning tasks, and to test its dependency on integrity of the hippocampus and susceptibility to modulation of non-contingent stress, epinephrine or amphetamine. Studies in the second year aim to test the specificity and durability of memory enhancement in latent learning caused by epinephrine and roles of the amygdala and norepineprhine therein in this effect. Studies in the third year aim to test the hypothesis that the hippocampus is a target for amygdala influences activated by epinephrine, which are mediated via the ST and septohippocampal cholinergic fibers. In addition, the present project is also going to study with the fMRI method neural activation in various brain regions including the amygdala and hippocampus in response to conditioned fear stimuli and/or epinephrine.情緒記憶情境記憶潛伏學習杏仁核海馬終紋腎上腺素正腎上腺素乙醯膽鹼affective memorycontextual memorylatent learningamygdalahippocampusstria terminalisepinephrinenorepinephrineacetylcholine.