WEN-YING LINCHIH-PENG LINCHIH-HUNG HSULee, Ying HuiYing HuiLeeLin, Yi TingYi TingLinHsu, Meng ChiMeng ChiHsuYU-YUN SHAO2020-04-092020-04-092017-09-2600070920https://scholars.lib.ntu.edu.tw/handle/123456789/484032© 2017 Cancer Research UK. All rights reserved. Background:Totally implantable vascular access device (TIVAD)-related complications interfere in the anticancer treatment and increase medical expenses. We examined whether the implantation side of central line TIVADs is associated with the occurrence of thrombotic or occlusion events.Methods:We enrolled patients with cancer who required central line TIVADs and randomised them to receive the TIVAD implantation on either the left or right side. The primary endpoint was the occurrence of catheter-related thrombotic or occlusion events.Results:We randomised 240 patients, of which 235 received TIVAD implantation according to the protocol. In the per-protocol cohort, 117 and 118 patients received implantation on the left and right sides, respectively. Catheter-related thrombotic or occlusion events occurred in 9 (4%) patients, accounting for 0.065 events per 1000 catheter-days. Between the patients with left-and right-sided implantations, the occurrence rates (P=0.333) and the time from catheter implantation to the occurrence of thrombotic or occlusion events (P=0.328) were both similar. In the multivariate analysis, the side of implantation remained unassociated with the occurrence of thrombotic or occlusion events.Conclusions:The side of central line TIVAD implantation was not associated with the occurrence of catheter-related thrombotic or occlusion events in patients with cancer.cancer | catheter-related infection | central catheter | thrombosiscancer; catheter-related infection; central catheter; thrombosis[SDGs]SDG3D dimer; fibrinogen; antineoplastic agent; adult; artery puncture; Article; cancer patient; candidiasis; catheter infection; catheter occlusion; catheter removal; catheter sheath; catheter thrombosis; central venous catheterization; cohort analysis; controlled study; female; fibrinogen blood level; follow up; Gram negative infection; Gram positive infection; human; implantable port system; intraluminal thrombosis; left sided totally implantable vascular access device implantation; lymphoma; major clinical study; male; middle aged; observational study; priority journal; randomized controlled trial; right sided totally implantable vascular access device implantation; Staphylococcus epidermidis; Staphylococcus infection; superior cava vein; totally implantable vascular access device; treatment outcome; vascular access device; vascular guide wire; vein puncture; vein thrombosis; adverse effects; aged; Catheter Obstruction; Catheter-Related Infections; catheterization; device failure; Neoplasms; procedures; vascular access device; Venous Thrombosis; Aged; Antineoplastic Agents; Catheter Obstruction; Catheter-Related Infections; Catheterization, Peripheral; Equipment Failure; Female; Follow-Up Studies; Humans; Male; Middle Aged; Neoplasms; Vascular Access Devices; Venous Thrombosisjournal article10.1038/bjc.2017.264287874312-s2.0-85029899801https://api.elsevier.com/content/abstract/scopus_id/85029899801