Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristics

WAN-CHEN WUPeng, Kang-YungKang-YungPengJIN-YING LUCHIEH-KAI CHANCHIH-YUAN WANGFEN-YU TSENGWEI-SHIUNG YANGYEN-HUNG LINPO-CHIH LINChen, Ting-ChuTing-ChuChenKUO-HOW HUANGChueh, Jeff SJeff SChuehVIN-CENT WU2022-10-282022-10-282022-10-0108044643https://scholars.lib.ntu.edu.tw/handle/123456789/624093Concurrent autonomous cortisol secretion (ACS) in patients with primary aldosteronism (PA) is being reported more frequently. Several somatic mutations including PRKACA, GNAS, and CTNNB1 were identified in cortisol-producing adenomas (CPAs). The presence of these mutations in unilateral PA (uPA) patients concurrent with ACS (uPA/ACS) is not well known. This study aimed to investigate the prevalence of these mutations and their clinical vs pathological characteristics in uPA/ACS.en[SDGs]SDG3Cortisol-producing adenoma-related somatic mutations in unilateral primary aldosteronism with concurrent autonomous cortisol secretion: their prevalence and clinical characteristicsjournal article10.1530/EJE-22-0286359003232-s2.0-85138449279