SHANG-TZEN CHANG2018-09-102018-09-102008http://www.scopus.com/inward/record.url?eid=2-s2.0-43849093857&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/338513In this study, chemical compositions of hydrodistilled essential oil and anti-inflammatory activities from the twigs of Cinnamomum osmophloeum Kaneh. were investigated for the first time. The chemical constituents of the twig essential oil were further analyzed by GC-MS and they were found to be l-bornyl acetate (15.89%), caryophyllene oxide (12.98%), γ-eudesmol (8.03%), β-caryophyllene (6.60%), T-cadinol (5.49%), δ-cadinene (4.79%), trans-β-elemenone (4.25%), cadalene (4.19%), and trans-cinnamaldehyde (4.07%). The effects of essential oil on nitric oxide (NO) and prostaglandin E2 (PGE2) production in lipopolysaccharide (LPS)-activated RAW 264.7 macrophages were also examined. Results of nitric oxide tests indicated that twig essential oil and its major constituents such as trans-cinnamaldehyde, caryophyllene oxide, l-borneol, l-bornyl acetate, eugenol, β-caryophyllene, E-nerolidol, and cinnamyl acetate have excellent activities. These findings demonstrated that essential oil of C. osmophloeum twigs have excellent anti-inflammatory activities and thus have great potential to be used as a source for natural health products. ? 2007 Elsevier Ltd. All rights reserved.Anti-inflammation; Cinnamomum osmophloeum; Essential oil; trans-Cinnamaldehyde; Twigs[SDGs]SDG3Alcohols; Aldehydes; Nitric oxide; Polysaccharides; Anti-inflammation; Cinnamomum osmophloeum; Trans-Cinnamaldehyde; Essential oils; beta elemenone; borneol; bornyl acetate; cadalene; caryophyllene; caryophyllene oxide; cinnamaldehyde; Cinnamomum osmophloeum extract; cinnamyl acetate; curcumin; delta cadinene; delta cadinol; delta calacorene; elemicin; essential oil; estragole; eudesmol; eugenol; guaiol acetate; lipopolysaccharide; nerolidol; nitric oxide; plant extract; prostaglandin E2; sesquiterpene derivative; spathulenol; T cadinol; terpene; terpineol; acrolein; antiinflammatory agent; cinnamaldehyde; curcumin; drug derivative; essential oil; lipopolysaccharide; nitric oxide; prostaglandin E2; Alcohols; Aldehydes; Essential oils; Nitric oxide; Polysaccharides; bark; chemical composition; essential oil; gas chromatography; mass spectrometry; nitric oxide; organic compound; animal cell; antiinflammatory activity; article; cell viability; Cinnamomum; Cinnamomum osmophloeum; concentration response; controlled study; drug cytotoxicity; gas chromatography; human; human cell; IC 50; mass spectrometry; mouse; nonhuman; priority journal; protein synthesis; animal; biosynthesis; cell death; cell line; chemistry; Cinnamomum; drug effect; Cinnamomum osmophloeum; Cinnamomum verum; Acrolein; Animals; Anti-Inflammatory Agents; Cell Death; Cell Line; Cinnamomum; Curcumin; Dinoprostone; Humans; Lipopolysaccharides; Mice; Nitric Oxide; Oils, Volatilejournal article10.1016/j.biortech.2007.07.0502-s2.0-43849093857