JANN-YUAN WANGLee M.-C.Chang J.-H.Yu M.-C.VIN-CENT WUHuang K.-L.Chao K.-M.Chao K.-M.Lee C.-H.2020-08-132020-08-1320151323-7799https://www.scopus.com/inward/record.uri?eid=2-s2.0-84945436850&doi=10.1111%2fresp.12612&partnerID=40&md5=397b9d255463be8fedae48782878ad9dhttps://scholars.lib.ntu.edu.tw/handle/123456789/512447Background and objective This retrospective national surveillance study investigated the burden of and risk factors for nosocomial exposure of pulmonary tuberculosis (TB) in intensive care units. Methods Patients admitted to intensive care units were identified from the National Health Insurance Research Database. During 2004-2009, there were 1-387-707 intensive care unit admissions of 900-562 adult patients. Pulmonary tuberculosis association was considered if the patient was diagnosed with pulmonary tuberculosis during admission or within 3 months after discharge. Nosocomial transmissible period was calculated based on the length of anti-tuberculosis treatment and negative-pressure isolation during admission. Results Pulmonary tuberculosis was associated with 1.20% of all intensive care unit admissions and 6731 (38.9%) started anti-TB treatment during admission. For the other 10-583 admissions, the diagnosis was made after discharge and anti-TB treatment was not prescribed during admission. The probability paralleled the regional tuberculosis incidence. On average, 2794 pulmonary tuberculosis associated intensive care unit admissions contributed to 42-999-44-062 days of nosocomial exposure per year. The length of nosocomial transmissible period decreased with the gradual implementation of Mycobacterium tuberculosis nucleic acid amplification tests in intensive care practice. Multivariate linear regression analysis revealed that the length of nosocomial transmissible period was inversely associated with male gender, airway symptoms prior to admission and performing M. tuberculosis nucleic acid amplification tests and mycobacterial culture. Conclusions Nosocomial tuberculosis exposure is not uncommon in intensive care units. Performing rapid molecular diagnostic tests in those suspected of tuberculosis is recommended to reduce the risk of nosocomial exposure. Burden of nosocomial tuberculosis exposure in intensive care units was investigated. Pulmonary tuberculosis was associated with 1.20% of all intensive care unit admissions in Taiwan, contributing to 42-999-44-062 days of nosocomial exposure per year. The risk may be reduced by incorporating a rapid diagnostic tool in hospital infection control policy. ? 2015 The Authors. Respirology published by Wiley Publishing Asia Pty Ltd on behalf of Asian Pacific Society of Respirology.[SDGs]SDG3adult; Article; cohort analysis; comorbidity; disease association; female; hospital admission; hospital discharge; hospital infection; human; intensive care unit; lung tuberculosis; major clinical study; male; Mycobacterium tuberculosis; nucleic acid amplification; priority journal; risk factor; sensitivity analysis; aged; cross infection; genetics; incidence; intensive care unit; microbiology; middle aged; Mycobacterium tuberculosis; nucleic acid amplification; retrospective study; sex difference; statistics and numerical data; Taiwan; time factor; transmission; Tuberculosis, Pulmonary; very elderly; tuberculostatic agent; Aged; Aged, 80 and over; Antitubercular Agents; Cross Infection; Female; Humans; Incidence; Intensive Care Units; Male; Middle Aged; Mycobacterium tuberculosis; Nucleic Acid Amplification Techniques; Patient Discharge; Retrospective Studies; Risk Factors; Sex Factors; Taiwan; Time Factors; Tuberculosis, Pulmonaryjournal article10.1111/resp.12612264376262-s2.0-84945436850