2011-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/682888摘要：此計畫中我們提出藉由蒐集大量批次結晶的動態模型和在相同的比較基準(common basis)下來探討二級成核作用對於批次結晶槽操作上的影響。雖然有許多學者已提出成核以及結晶的動力模式，但是因為各種動力模式其表示方式上的差異，難以相比較其文獻報告結果。例如：不同學者用不同的成核以及結晶的經驗表示式或是用不同的比較基準，像是用晶體的moments或是結晶槽中的溶質濃度當作比較基準。因此在此計畫中，我們提出用文獻中各種不同結晶(溶質溶劑不同)的動態模式來模擬批次結晶程序，加以回歸其模擬結果成一種模型(model)的表達方式。對於不同結晶的系統，同時決定結晶的臨界晶種載入量(critical seed loading)與晶種平均大小的數學關係式，並且決定在特定的晶種大小下操作的最適化溫度函數(cooling trajectory)。上述研究成果可有效率的應用於快速設計(rapid development)晶種批次結晶程序操作。<br> Abstract: We propose to investigate the effect of secondary nucleation on the operation of batch crystallizers by collecting a large number of models of batch crystallization dynamics from the literature and studying them using a common basis. Many authors have reported kinetic models for crystal nucleation and growth in the literature; however the results are difficult to compare because of differences in the modeling. For example, different researchers may use different empirical expressions for the crystal nucleation and growth rate or a different basis for the crystal moments and concentration. We propose to simulate the operation of batch crystallization processes using a number of different models reported in the literature for different solute-solvent systems, and then regress the data from each simulation to a single model. For each system, we will also determine the critical seed loading as a function of average seed size and the optimal cooling trajectory for a specific seed size. The results will be useful for the rapid development of recipes for the operation of seeded batch crystallization.批次結晶成核長晶batch crystallizationcrystal nucleationcrystal growth