Williamson, AliceAliceWilliamsonNorris, Dougall MDougall MNorrisYin, XianyongXianyongYinBroadaway, K AlaineK AlaineBroadawayMoxley, Anne HAnne HMoxleyVadlamudi, SwarooparaniSwarooparaniVadlamudiWilson, Emma PEmma PWilsonJackson, Anne UAnne UJacksonAhuja, VasudhaVasudhaAhujaAndersen, Mette KMette KAndersenArzumanyan, ZorayrZorayrArzumanyanBonnycastle, Lori LLori LBonnycastleBornstein, Stefan RStefan RBornsteinBretschneider, Maxi PMaxi PBretschneiderBuchanan, Thomas AThomas ABuchananYI-CHENG CHANGLEE-MING CHUANGChung, Ren-HuaRen-HuaChungClausen, Tine DTine DClausenDamm, PeterPeterDammDelgado, Graciela EGraciela EDelgadode Mello, Vanessa DVanessa Dde MelloDupuis, JoséeJoséeDupuisDwivedi, Om POm PDwivediErdos, Michael RMichael RErdosSilva, Lilian FernandesLilian FernandesSilvaFrayling, Timothy MTimothy MFraylingGieger, ChristianChristianGiegerGoodarzi, Mark OMark OGoodarziGuo, XiuqingXiuqingGuoGustafsson, StefanStefanGustafssonHakaste, LiisaLiisaHakasteHammar, UlfUlfHammarHatem, GadGadHatemHerrmann, SandraSandraHerrmannHøjlund, KurtKurtHøjlundHorn, KatrinKatrinHornHsueh, Willa AWilla AHsuehHung, Yi-JenYi-JenHungHwu, Chii-MinChii-MinHwuJonsson, AnnaAnnaJonssonKårhus, Line LLine LKårhusKleber, Marcus EMarcus EKleberKovacs, PeterPeterKovacsLakka, Timo ATimo ALakkaLauzon, MarieMarieLauzonLee, I-TeI-TeLeeLindgren, Cecilia MCecilia MLindgrenLindström, JaanaJaanaLindströmLinneberg, AllanAllanLinnebergLiu, Ching-TiChing-TiLiuLuan, Jian'anJian'anLuanAly, Dina MansourDina MansourAlyMathiesen, ElisabethElisabethMathiesenMoissl, Angela PAngela PMoisslMorris, Andrew PAndrew PMorrisNarisu, NarisuNarisuNarisuPerakakis, NikolaosNikolaosPerakakisPeters, AnnetteAnnettePetersPrasad, Rashmi BRashmi BPrasadRodionov, Roman NRoman NRodionovRoll, KathrynKathrynRollRundsten, Carsten FCarsten FRundstenSarnowski, ChloéChloéSarnowskiSavonen, KaiKaiSavonenScholz, MarkusMarkusScholzSharma, SapnaSapnaSharmaStinson, Sara ESara EStinsonSuleman, SufyanSufyanSulemanTan, JingyiJingyiTanTaylor, Kent DKent DTaylorUusitupa, MattiMattiUusitupaVistisen, DorteDorteVistisenWitte, Daniel RDaniel RWitteWalther, RomyRomyWaltherWu, PeitaoPeitaoWuXiang, Anny HAnny HXiangZethelius, BjörnBjörnZetheliusAhlqvist, EmmaEmmaAhlqvistBergman, Richard NRichard NBergmanChen, Yii-Der IdaYii-Der IdaChenCollins, Francis SFrancis SCollinsFall, ToveToveFallFlorez, Jose CJose CFlorezFritsche, AndreasAndreasFritscheGrallert, HaraldHaraldGrallertGroop, LeifLeifGroopHansen, TorbenTorbenHansenKoistinen, Heikki AHeikki AKoistinenKomulainen, PirjoPirjoKomulainenLaakso, MarkkuMarkkuLaaksoLind, LarsLarsLindLoeffler, MarkusMarkusLoefflerMärz, WinfriedWinfriedMärzMeigs, James BJames BMeigsRaffel, Leslie JLeslie JRaffelRauramaa, RainerRainerRauramaaRotter, Jerome IJerome IRotterSchwarz, Peter E HPeter E HSchwarzStumvoll, MichaelMichaelStumvollSundström, JohanJohanSundströmTönjes, AnkeAnkeTönjesTuomi, TiinamaijaTiinamaijaTuomiTuomilehto, JaakkoJaakkoTuomilehtoWagner, RobertRobertWagnerBarroso, InêsInêsBarrosoWalker, MarkMarkWalkerGrarup, NielsNielsGrarupBoehnke, MichaelMichaelBoehnkeWareham, Nicholas JNicholas JWarehamMohlke, Karen LKaren LMohlkeWheeler, EleanorEleanorWheelerO'Rahilly, StephenStephenO'RahillyFazakerley, Daniel JDaniel JFazakerleyLangenberg, ClaudiaClaudiaLangenberg2023-07-172023-07-172023-061061-40361546-1718https://scholars.lib.ntu.edu.tw/handle/123456789/633800Distinct tissue-specific mechanisms mediate insulin action in fasting and postprandial states. Previous genetic studies have largely focused on insulin resistance in the fasting state, where hepatic insulin action dominates. Here we studied genetic variants influencing insulin levels measured 2 h after a glucose challenge in >55,000 participants from three ancestry groups. We identified ten new loci (P < 5 × 10-8) not previously associated with postchallenge insulin resistance, eight of which were shown to share their genetic architecture with type 2 diabetes in colocalization analyses. We investigated candidate genes at a subset of associated loci in cultured cells and identified nine candidate genes newly implicated in the expression or trafficking of GLUT4, the key glucose transporter in postprandial glucose uptake in muscle and fat. By focusing on postprandial insulin resistance, we highlighted the mechanisms of action at type 2 diabetes loci that are not adequately captured by studies of fasting glycemic traits.en[SDGs]SDG3journal article10.1038/s41588-023-01408-9372911942-s2.0-85161434094https://api.elsevier.com/content/abstract/scopus_id/85161434094