Chiu, P.-Cin-ChiP.-Cin-ChiChiuCHIH-CHIEH CHANLin, Hui-MinHui-MinLinHSIEN-CHING CHIU2019-12-052019-12-0520071473-2130https://www.scopus.com/inward/record.uri?eid=2-s2.0-36749091197&doi=10.1111%2fj.1473-2165.2007.00342.x&partnerID=40&md5=2a743a1387925c7e927b38cda7bc6532https://scholars.lib.ntu.edu.tw/handle/123456789/435094Background: Kinetin and niacinamide are used in the cosmetic industry as anti-aging agents. Neither the interactive/additive effects of these compounds nor the anti-aging efficacy on Asian skin has been studied. Objective: To assess the clinical anti-aging effects and efficacy differences between kinetin plus niacinamide and niacinamide alone vs. vehicle placebo in an Asian cohort. Methods: Fifty-two Taiwanese subjects were enrolled in a randomized, double-blind, placebo-controlled, split-face comparative study. Group 1 subjects were treated with kinetin 0.03% plus niacinamide 4%, whereas group 2 subjects received niacinamide 4%. The treatment formulation was applied on one side of the face, whereas a placebo was applied on the other for a period of 12.weeks. We used noninvasive biometrological instruments to evaluate a variety of skin parameters at baseline and at weeks 4, 8, and 12. Results: Persistent and significant reductions in spot, pore, wrinkle, and evenness counts were found at weeks 8 and 12 in group 1. A significant increase in corneal hydration status was also evident at week 12, whereas persistent decreases in erythema index were apparent at 8 and 12.weeks. In group 2, significant reductions in pore and evenness counts at week 8 and wrinkle counts at week 12 were noted. Conclusion: We found kinetin and niacinamide exert a synergistic anti-aging effect. Our data suggest that these compounds have multiactive, multifunctional, and pluripotent effects on skin. They are also both promising to be included in the cutaneous anti-aging cosmeceuticals in the future. ? 2007 Blackwell Publishing.en[SDGs]SDG3kinetin; nicotinamide; placebo; adult; aging; article; Asia; biometry; comparative study; controlled study; cornea edema; cutaneous parameters; erythema; human; human experiment; hydration; non invasive procedure; priority journal; skin care; wrinkle; Administration, Cutaneous; Adult; Asian Continental Ancestry Group; Dermatologic Agents; Double-Blind Method; Drug Therapy, Combination; Female; Humans; Kinetin; Male; Middle Aged; Niacinamide; Severity of Illness Index; Skin Aging; Taiwan; Treatment Outcomejournal article10.1111/j.1473-2165.2007.00342.x180476092-s2.0-36749091197