Wang P.-SLiang C.-KMAN-KIT LEUNG2022-12-142022-12-14200500404020https://www.scopus.com/inward/record.uri?eid=2-s2.0-14344256681&doi=10.1016%2fj.tet.2005.01.063&partnerID=40&md5=bd5d9a10e83ae7c567f1669a98ecafc8https://scholars.lib.ntu.edu.tw/handle/123456789/626210An effective CuI-trans-N,N′-dimethylcyclohexane-1,2-diamine (DMCDA)-K2CO3-catalyzed coupling reaction of 2-pyridones with aryl halides is described. Under our conditions, DMCDA was found to be an effective catalyst that facilitates the coupling reactions even in toluene, a common industrial solvent. In addition, 3-bromopyridine could also be coupled effectively under these conditions, indicating that the catalytic reactivity of this system is high. The reaction could be applied for polymer modification and iterative oligo-pyridone synthesis. © 2005 Elsevier Ltd. All rights reserved.2-Pyridones; C-N coupling; Copper reagents; Toluenecopper derivative; halide; pyridone derivative; toluene; article; catalysis; chemical modification; chemical reaction kinetics; priority journaljournal article10.1016/j.tet.2005.01.0632-s2.0-14344256681