YI-WEN CHENHou, Yu-WenYu-WenHouWang, Chuang-WeiChuang-WeiWangSHIH-JUNG CHENGWEI-TING KUOCHUN-PIN LINHSIN-HAN HOU2024-03-292024-03-292024-02-2220411006https://scholars.lib.ntu.edu.tw/handle/123456789/641640The worldwide prevalence of periodontitis is considerably high, and its pathogenic mechanisms must be investigated and understood in order to improve clinical treatment outcomes and reduce the disease prevalence and burden. The exacerbation of the host immune system induced by oral microbial dysbiosis and the subsequent tissue destruction are the hallmarks of the periodontitis. However, the oral bacteria involved in periodontitis are not fully understood. We used the Oxford Nanopore Technologies (ONT) sequencing system to analyze metagenomic information in subgingival dental plaque from periodontitis and non-periodontitis patients. The number of Lactobacillus zeae (L. zeae) in the periodontitis patients was 17.55-fold higher than in the non-periodontitis patients, suggesting that L. zeae is a novel periodontitis-associated pathogen. Although several Lactobacillus species are used in vivo as probiotics to treat periodontitis and compete with Porphyromonas gingivalis (P. gingivalis), the roles of L. zeae in periodontitis progression, and the relationship between L. zeae and P. gingivalis needs to be investigated.enLactobacillus zeae; Porphyromonas gingivalis; ligature-implanted mice; metagenomic sequencing; periodontitis[SDGs]SDG3journal article10.1111/omi.12455383858322-s2.0-85186460252https://api.elsevier.com/content/abstract/scopus_id/85186460252