Wu Y.-H.Wu Y.-C.SHIH-JUNG CHENGKuo Y.-S.Sun A.HSIN-MING CHEN2021-07-072021-07-0720190929-6646https://www.scopus.com/inward/record.uri?eid=2-s2.0-85066983924&doi=10.1016%2fj.jfma.2019.05.017&partnerID=40&md5=6cfd419ed1e4107ce982fb120abd56f8https://scholars.lib.ntu.edu.tw/handle/123456789/570380Background/Purpose: Gastric parietal cell antibody (GPCA), thyroglobulin antibody (TGA), and thyroid microsomal antibody (TMA) may be present in oral mucosal disease patients. This study mainly assessed the frequencies of serum GPCA, TGA, and TMA positivities in 131 oral precancer patients. Methods: Serum GPCA, TGA, and TMA levels were measured in 131 oral precancer patients including 96 oral leukoplakia, 26 oral erythroleukoplakia, and 9 oral verrucous hyperplasia patients and in 131 age- and sex-matched healthy control subjects. Results: We found that 131 oral precancer patients had higher frequencies of serum GPCA (10.7% vs. 2.3%, P = 0.012, statistically significant), TGA (4.6% vs. 2.3%, P = 0.498), and TMA (8.4% vs. 2.3%, P = 0.054, marginal significance) positivities than 131 healthy control subjects. We also found that 1 (0.8%), 6 (4.6%), and 16 (12.2%) oral precancer patients had the presence of three (GPCA + TGA + TMA), two (GPCA + TGA, GPCA + TMA, or TGA + TMA), or one (GPCA only, TGA only, or TMA only) autoantibody in their sera, respectively. Of 10 TGA/TMA-positive oral precancer patients whose serum thyroid-stimulating hormone (TSH) levels were measured, 80%, 10%, and 10% of these 10 TGA/TMA-positive oral precancer patients had normal, lower, and higher serum TSH levels, respectively. We also found a significantly higher GPCA positive rate in 26 smokers consuming >20 cigarettes per day than in 61 smokers consuming ?20 cigarettes per day (P = 0.008). Conclusion: Approximately 17.6% of 131 oral precancer patients have serum GPCA/TGA/TMA positivity. Only approximately 20% of TGA/TMA-positive oral precancer patients have either hypothyroidism or hyperthyroidism. ? 2019[SDGs]SDG3microsome antibody; parietal cell antibody; thyroglobulin antibody; thyroid antibody; anti-thyroglobulin; autoantibody; thyroid microsomal antibodies; thyrotropin; adult; aged; Article; betel quid; blood sampling; cancer diagnosis; cigarette smoking; comparative study; controlled study; epithelium hyperplasia; female; human; hyperkeratosis; hyperthyroidism; hypothyroidism; leukoplakia; major clinical study; male; mouth cancer; parakeratosis; people by drinking status; precancer; smoking habit; stomach parietal cell; thyrotropin blood level; blood; case control study; hyperplasia; immunology; middle aged; mouth mucosa; mouth tumor; pathology; smoking; stomach parietal cell; Adult; Aged; Autoantibodies; Case-Control Studies; Female; Humans; Hyperplasia; Leukoplakia, Oral; Male; Middle Aged; Mouth Mucosa; Mouth Neoplasms; Parietal Cells, Gastric; Smoking; Thyrotropinjournal article10.1016/j.jfma.2019.05.017312009992-s2.0-85066983924