Chang R.Hsu C.-F.Tsai W.-B.2019-05-282019-05-28201824701343https://scholars.lib.ntu.edu.tw/handle/123456789/410733Nanogels have been widely used in biomedical applications, such as carriers for hyperthermia cancer treatment, drug delivery, and imaging. Owing to the enhanced permeability and retention effect, nanogels have shown a great potential in cancer therapy. In this study, sodium copper chlorophyllin (SCC), a low cytotoxicity and biodegradable photothermal agent, was copolymerized with a nanogel of N-[3-(dimethylamino)propyl]methacrylamide. The nanogels could produce heat under exposure to a green laser with a 532 nm wavelength. The positively charged nature of the nanogels enhanced the endocytosis of the nanogels. The cell mortality was greatly enhanced with the treatment of the SCC-containing nanogels and green light illumination. Our results suggest the potential of SCC-containing nanogels in photothermal cancer therapy. ? 2018 American Chemical Society.[SDGs]SDG3journal article10.1021/acsomega.8b016892-s2.0-85054522829https://www.scopus.com/inward/record.uri?eid=2-s2.0-85054522829&doi=10.1021%2facsomega.8b01689&partnerID=40&md5=f9e8f3546d8075139b18c3c35a661e4a