Lin, Shin-PingShin-PingLinYi, Tsung-KaiTsung-KaiYiKao, Yi-FengYi-FengKaoTu, Ming-ChiehMing-ChiehTuHsieh, Chen-CheChen-CheHsiehShen, Szu ChuanSzu ChuanShenChou, Yu-ChiehYu-ChiehChouLu, Jheng-JheJheng-JheLuSantoso, Shella PermatasariShella PermatasariSantosoChai, Huey-JineHuey-JineChaiKUAN-CHEN CHENG2026-02-252026-02-252026-0301418130https://www.scopus.com/pages/publications/105029564969https://scholars.lib.ntu.edu.tw/handle/123456789/735977Article number 150838In this study, we developed a dextran-modified foaming bacterial cellulose (FBC) hydrogel that utilized foam medium with dextran in situ. The resulting dextran/FBC hydrogel exhibited a high water content (92.3%–94.2%) and enhanced epithelial cell proliferation compared to unmodified FBC (79.1% vs. 68.4%). Furthermore, the combination of dextran/FBC with Botryocladia leptopoda extract (AE) further improved cell proliferation to 97.1%. In vivo wound-healing experiments in mice demonstrated that AE-loaded dextran/FBC achieved the most effective wound remodeling, with a normal epidermal thickness and regeneration of functional structures such as pores and hair follicles by day 12. This biomaterial can be directly produced from microbial biosynthesis with no post-modification. Its biodegradability, sustainable green production process, and great wound-remodeling capacity highlight its potential as a novel moist wound dressing.falseBotryocladia leptopodaDextranFoaming bacterial celluloseWound dressingWound healingjournal article10.1016/j.ijbiomac.2026.1508382-s2.0-105029564969