2016-08-012024-05-17https://scholars.lib.ntu.edu.tw/handle/123456789/670888摘要：在細胞受病毒感染的幾分鐘至數小時之內，先天性抗病毒反應啟動，並且透過誘導第一型和第三型干擾素和干擾素刺激基因（ISG）的表達，能夠迅速將被感染及其鄰近的細胞設定在抗病毒狀態。為了抵抗宿主所產生的抗病毒先天免疫，若干病毒蛋白酶會鎖定關鍵第一型干擾素誘導途徑中的蛋白質，如HCV NS3 / 4A 裂解MAVS 和登革病毒的NS2B/3 裂解STING。但是在宿主細胞蛋白酶是否能夠調空第一型干擾素的表現仍未被了解，應評估他們的角色。在這裡，我們提出，研究嵌膜絲氨酸蛋白酶家族在抗病毒先天免疫的作用及其機制。<br> Abstract: Anti-viral innate responses occur within minutes to hours upon virusinfections and rapidly set the infected and the neighbouring cells in the anti-viralstate by inducing the expression of type I/III interferons (IFNs) and theinterferon stimulated genes (ISGs). To counteract host antiviral innate immunity,several viral proteases have been shown to target crucial adaptor proteins in thetype I IFN induction pathway, such as MAVS cleavage by HCV NS3/4A andSTING cleavage by DENV NS2B/3. Cellular proteases in the host, however,have not been assessed their roles in controlling type I IFN inductions andresponses. Here we propose to study the roles of Transmembrane protease, serinefamily in anti-viral innate immunity.