JYH-MING LIOUJiang, Xiao-TaoXiao-TaoJiangCHIEH-CHANG CHENLuo, Jiing-ChyuanJiing-ChyuanLuoBair, Ming-JongMing-JongBairChen, Po-YuehPo-YuehChenChou, Chu-KuangChu-KuangChouYU-JEN FANGMEI-JYH CHENLee, Ji-YuhJi-YuhLeeCHIEN-CHUAN CHENYang, Tsung-HuaTsung-HuaYangYu, Chien-ChunChien-ChunYuKuo, Chia-ChiChia-ChiKuoChiu, Min-ChinMin-ChinChiuChen, Chi-YiChi-YiChenCHIA-TUNG SHUNWEN-HAO HUTsai, Min-HornMin-HornTsaiHsu, Yao-ChunYao-ChunHsuTseng, Cheng-HaoCheng-HaoTsengChang, Chi-YangChi-YangChangJAW-TOWN LINEl-Omar, Emad MEmad MEl-OmarMING-SHIANG WUWu, Chun-YingChun-YingWuYI-CHIA LEEPING-HUEI TSENGWu, Jeng-YihJeng-YihWuTai, Chi-MingChi-MingTaiLee, Ching-TaiChing-TaiLeeWang, Wen-LunWen-LunWang2023-02-172023-02-172023-0324681253https://scholars.lib.ntu.edu.tw/handle/123456789/628279https://www.scopus.com/record/display.uri?eid=2-s2.0-85147659187&doi=10.1016%2fS2468-1253%2822%2900384-3&origin=inward&txGid=45f2e44263e75d8498b99bbd2ca746a8Levofloxacin-based therapy or bismuth-based quadruple therapy are the recommended second-line regimens for Helicobacter pylori eradication after failure of clarithromycin-based therapy. However, resistance to levofloxacin has increased in the past decade. Furthermore, little is known about the long-term effects of H pylori eradication on the antibiotic resistome. In this study, we compared these second-line eradication therapies for efficacy, tolerability, and short-term and long-term effects on the gut microbiota, antibiotic resistome, and metabolic parameters.en[SDGs]SDG3Second-line levofloxacin-based quadruple therapy versus bismuth-based quadruple therapy for Helicobacter pylori eradication and long-term changes to the gut microbiota and antibiotic resistome: a multicentre, open-label, randomised controlled trialjournal article10.1016/S2468-1253(22)00384-3365493202-s2.0-85147659187