Wang Y.-P.Liao Y.-T.Liu C.-H.Yu J.Alamri H.R.Alothman Z.A.Hossain M.S.A.Yamauchi Y.Wu K.C.-W.2019-05-242019-05-24201723739878https://scholars.lib.ntu.edu.tw/handle/123456789/410335Chemotherapy of bladder cancer has limited efficacy because of the short retention time of drugs in the bladder during therapy. In this research, nanoparticles (NPs) with a new core/shell/corona nanostructure have been synthesized, consisting of iron oxide (Fe 3 O 4 ) as the core to providing magnetic properties, drug (doxorubicin) loaded calcium phosphate (CaP) as the shell for pH-responsive release, and arginylglycylaspartic acid (RGD)-containing peptide functionalized alginate as the corona for cell targeting (with the composite denoted as RGD-Fe 3 O 4 /CaP/Alg NPs). We have optimized the reaction conditions to obtain RGD-Fe 3 O 4 /CaP/Alg NPs with high biocompatibility and suitable particle size, surface functionality, and drug loading/release behavior. The results indicate that the RGD-Fe 3 O 4 /CaP/Alg NPs exhibit enhanced chemotherapy efficacy toward T24 bladder cancer cells, owing to successful magnetic guidance, pH-responsive release, and improved cellular uptake, which give these NPs great potential as therapeutic agents for future in vivo drug delivery systems. ? 2017 American Chemical Society.bladder cancercontrolled releasecore-shell-corona nanoparticlesmagnetic guidancetargeting[SDGs]SDG3Biocompatibility; Chemotherapy; Diseases; Iron research; Magnetism; Nanoparticles; Nanostructures; Particle size; Shells (structures); Synthesis (chemical); Bladder cancer cells; Bladder cancers; Controlled release; Core shell; Drug delivery system; Surface functionalities; Targeted chemotherapy; targeting; Nanomagnetics; alginic acid; arginylglycylaspartic acid; calcium phosphate; doxorubicin; superparamagnetic iron oxide nanoparticle; Article; biocompatibility; bladder cancer; cancer chemotherapy; controlled study; drug delivery system; drug efficacy; drug release; drug targeting; human; human cell; magnetic field; particle size; pH; priority journal; reaction optimization; surface property; T24 cell line; target celljournal article10.1021/acsbiomaterials.7b002302-s2.0-85030856334https://www.scopus.com/inward/record.uri?eid=2-s2.0-85030856334&doi=10.1021%2facsbiomaterials.7b00230&partnerID=40&md5=49a81c4a7b32b5f1360ca8be3623b2d3