Lin, Chao-NanChao-NanLinChan, Kuan RongKuan RongChanOoi, Eng EongEng EongOoiChiou, Ming-TangMing-TangChiouHoang, MinhMinhHoangPO-REN HSUEHOoi, Peck ToungPeck ToungOoi2022-04-282022-04-2820211999-4915https://scholars.lib.ntu.edu.tw/handle/123456789/608270Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), a novel coronavirus in humans, has expanded globally over the past year. COVID-19 remains an important subject of intensive research owing to its huge impact on economic and public health globally. Based on historical archives, the first coronavirus-related disease recorded was possibly animal-related, a case of feline infectious peritonitis described as early as 1912. Despite over a century of documented coronaviruses in animals, the global animal industry still suffers from outbreaks. Knowledge and experience handling animal coronaviruses provide a valuable tool to complement our understanding of the ongoing COVID-19 pandemic. In this review, we present an overview of coronaviruses, clinical signs, COVID-19 in animals, genome organization and recombination, immunopathogenesis, transmission, viral shedding, diagnosis, treatment, and prevention. By drawing parallels between COVID-19 in animals and humans, we provide perspectives on the pathophysiological mechanisms by which coronaviruses cause diseases in both animals and humans, providing a critical basis for the development of effective vaccines and therapeutics against these deadly viruses.enCOVID-19; DIVA; animal coronavirus; immunopathogenesis[SDGs]SDG3review10.3390/v13081507344523722-s2.0-85111705177WOS:000690151400001https://api.elsevier.com/content/abstract/scopus_id/85111705177