Yanuar Amal, MohamadMohamadYanuar AmalSHYH-JYE CHEN2026-04-232026-04-232025https://scholars.lib.ntu.edu.tw/handle/123456789/737467Objectives: This study aims to evaluate the prevalence and anatomical patterns of tracheobronchial anomalies and to analyze their associations with different types of congenital heart disease (CHD) using retrospective CT data. Introduction: Tracheobronchial anomalies, including variations in the branching patterns of the trachea and bronchi, are relatively rare but clinically significant. These anomalies, which are often associated with CHD, can complicate respiratory function and airway management. Despite their low prevalence, early identification and understanding of these anatomical variations are essential to improve patient outcomes. Methods: This retrospective study was conducted at the National Taiwan University Hospital and included patients who underwent computed tomography (CT) imaging between December 2012 and February 2024. The inclusion criteria were strictly defined to focus on patients diagnosed with a lobar or segmental tracheal bronchus anomaly, as identified on their initial CT scan. Results: Among 356 patients diagnosed with tracheobronchial anomalies, 223 had concurrent CHD. The study found a significant association between tracheobronchial anomalies and CHD, particularly in conditions such as a right-sided aortic arch and pulmonary atresia. In addition, the presence of persistent left superior vena cava was notably higher in patients with CHD. Discussion: The study accentuates the importance of early detection of tracheal bronchus anomalies, particularly in patients with CHD. Early detection through advanced imaging techniques is critical for minimizing complications. This study supports the “space availability” hypothesis of embryological development of these anomalies. Moreover, the significant association between tracheal bronchus and conditions such as pulmonary atresia and a right-sided aortic arch suggests a shared embryological pathway. Conclusion: Tracheobronchial anomalies are clinically significant, particularly in the context of CHD. Timely identification, coupled with a multidisciplinary approach, is crucial to enhancing patient outcomes and reducing complications. Future research should focus on the genetic and environmental factors that contribute to the development of these conditions.entruecomputed tomography (CT)congenital heart disease (CHD)persistent left superior vena cava (PLSVC)pulmonary atresiatracheobronchial anomaliesjournal article10.3389/fradi.2025.1697305418585632-s2.0-105033018843