2014-11-012024-05-15https://scholars.lib.ntu.edu.tw/handle/123456789/664997摘要：「光遺傳學」是一個結合光學與遺傳學的強大技術，能使科學家透過操弄光在組織或自由活動的動物上達到直接調控神經細胞神經脈衝，提供神經科學家前所未有的直接且即時的因果關係操弄。這個劃時代的技術在2010年分別被Nature及Science兩大期刊選為 Method of Year 2010及 Breakthroughs of the decade。這個技術被越來越多的研究用於從基礎神經功能到複雜認知功能等神經科學相關議題上。然而這個技術迄今尚未在台灣或台灣大學被完整的建立，特別是在活體動物身上。利用光遺傳學及相關技術，我們決定組成一個跨院的合作團隊，在台灣大學建立這套技術與相關配備。使用基因轉殖小鼠並配合光遺傳學相關技術來研究動機、決策、與動作選擇等功能的神經基礎。<br> Abstract: Optogenetics is a powerful new technique employed in neuroscience/biopsychology that uses a combination of techniques from optics and genetics to control the activity of individual neurons in living tissues or freely-moving animals. This groundbreaking new technique was chosen as the Method of the Year in 2010. It has been increasing used to study a number of neuroscience-related issues from basic neural functions to higher cognitive functions. However, this unique technique has not been fully established in Taiwan or in National Taiwan University, especially in behaving animals. Taking advantage of optogenetics and related techniques, we decide to work together and plan on establishing this cutting-edge new technique in National Taiwan University using genetically modified mice and use this method to study neural basis of motivation, decision making, and action selection.光遺傳學基因轉殖小鼠核心實驗室決策動作選擇optogeneticsgenetically modified micecore laboratorydecision makingaction selection