Cheng P.-WChiueh T.-DJYH-HORNG CHENTZI-DAR CHIUEH2022-04-252022-04-25202120452322https://www.scopus.com/inward/record.uri?eid=2-s2.0-85117223586&doi=10.1038%2fs41598-021-98132-3&partnerID=40&md5=913f9e3a8b68edde6e6c9a43edaf20a6https://scholars.lib.ntu.edu.tw/handle/123456789/607230Latest simultaneous multi-slice (SMS) methods greatly benefit MR efficiency for recent studies using parallel imaging technique. However, these methods are limited by the requirement of array coils. The proposed Coherent Wideband method, which employs an extended field of view to separate multiple excited slices, can be applied to any existing MRI instrument, even those without array coils. In this study, the Coherent Wideband echo-planar imaging method was implemented on 7?T animal MRI to exhibit comprehensive enhancements in neuro-architecture, including diffusion tensor imaging (DTI) and functional MR studies (fMRI). Under the same scan time, the time-saving effect can be manipulated to increase the number of averages for DTI SNR improvement, reducing fractional anisotropy difference by 56.9% (from 0.072 to 0.041) and the deviation angle by 64% (from 25.3° to 16.2°). In summary, Coherent Wideband Echo Planar Imaging (EPI) will provide faster, higher resolution, thinner slice, or higher SNR imaging for precision neuro-architecture studies. ? 2021, The Author(s).animal experimentarticlebraindiffusion tensor imagingecho planar imagingfractional anisotropynonhumanrodentanimalanisotropycomputer assisted diagnosisdevicesdiagnostic imagingmalenuclear magnetic resonance imagingproceduresratsignal noise ratioAnimalsAnisotropyBrainDiffusion Tensor ImagingEcho-Planar ImagingImage Interpretation, Computer-AssistedMagnetic Resonance ImagingMaleRatsSignal-To-Noise Ratio[SDGs]SDG3journal article10.1038/s41598-021-98132-3346423492-s2.0-85117223586