HSIN-YUN SUNCacciarelli T.V.Singh N.2020-12-292020-12-2920101527-6465https://www.scopus.com/inward/record.uri?eid=2-s2.0-75449098274&doi=10.1002%2flt.21982&partnerID=40&md5=d9d0cb8613c596b95306e18b3ef34b88https://scholars.lib.ntu.edu.tw/handle/123456789/535390Whether pretransplant nonviral infections influence outcomes after transplantation in liver transplant recipients in the current era is not well defined. One hundred consecutive patients undergoing liver transplantation in 2005-2008 were studied. Demographics, posttransplant clinical events, and mortality were compared between recipients with and without infections within 12 months before transplantation. In all, 32% of the patients (32/100) developed 45 episodes of pretransplant infections, which included spontaneous bacterial peritonitis (35.6%), bloodstream infections (28.9%), cellulitis (13.3%), pneumonia (8.9%), urinary tract infections (6.7%), and other infections (6.7%). Compared with 68 recipients without pretransplant infections, those with infections had a higher Model for End-Stage Liver Disease score and a lower likelihood of transplantation from home and required longer and more frequent hospital care before and after transplantation (P < 0.05). Mortality at 90 (9.4% versus 2.9%) and 180 days (15.6% versus 10.3%) post-transplant did not differ significantly between recipients with and without pretransplant infections (P = not significant). A higher Model for End-Stage Liver Disease score (P < 0.05) and posttransplant infections (P < 0.05 and P < 0.001), but not pretransplant infections, were associated with posttransplant mortality at 90 and 180 days. In conclusion, pretransplant infections that have been adequately treated do not pose a significant risk for poor outcomes, including posttransplant mortality. ? 2010 AASLD.[SDGs]SDG3ampicillin; cefotaxime; ganciclovir; methylprednisolone; prednisone; sulfamethoxazole; tacrolimus; trimethoprim; valganciclovir; adult; aged; antibiotic prophylaxis; article; bacterial peritonitis; bloodstream infection; candidiasis; cellulitis; controlled study; corticosteroid therapy; cytomegalovirus infection; demography; enterococcal infection; Escherichia coli infection; female; graft recipient; Gram negative infection; hepatitis C; hospital care; hospital readmission; human; intensive care unit; intubation; Klebsiella pneumoniae infection; liver graft; liver graft rejection; liver transplantation; low drug dose; major clinical study; male; outcome assessment; Pneumocystis pneumonia; pneumonia; postoperative care; postoperative infection; preoperative evaluation; priority journal; recurrent infection; reoperation; repeat procedure; scoring system; spontaneous bacterial peritonitis; Streptococcus infection; surgical mortality; urinary tract infection; vancomycin resistant Enterococcus; Adult; Aged; Bacterial Infections; Cellulitis; Comorbidity; Female; Humans; Liver Failure; Liver Transplantation; Male; Middle Aged; Pneumonia, Bacterial; Preoperative Period; Risk Factors; Urinary Tract Infectionsjournal article10.1002/lt.2198220104499