Yang, I-HsuanI-HsuanYangSzabó, LászlóLászlóSzabóSasaki, MakotoMakotoSasakiUto, KoichiroKoichiroUtoHenzie, JoelJoelHenzieLin, Feng-HueiFeng-HueiLinSamitsu, SadakiSadakiSamitsuEbara, MitsuhiroMitsuhiroEbara2026-02-052026-02-052023-12-3101418130https://www.scopus.com/pages/publications/85171424591?origin=resultslisthttps://scholars.lib.ntu.edu.tw/handle/123456789/735781Highly efficient adsorbents are needed to remove uremic toxins and reduce the economic and societal burden of the current dialysis treatments in resource-limited environments. In this study, nanostructured porous carbon nanofibers with nitrogen-doped zeolites (NZ-PCNF) were prepared, by electrospinning zeolites with chitosan-poly(ethylene oxide) blends, followed by a one-step carbonization process, without further activation steps or aggressive chemical additives for N-doping. The results showed that N-zeolites were successfully integrated into an ultrafine carbon nanofiber network, with a uniform nanofiber diameter of approximately 25 nm, hierarchical porous structure (micro- and mesopores), and high specific surface area (639.29 m2/g), facilitating uremic toxin diffusion and adsorption. The self-N-doped structure in the NZ-PCNF removed more creatinine (∼1.8 times) than the porous carbon nanofibers when using the same weight of precursor materials. Cytotoxicity and hemolysis tests were performed to verify the safety of NZ-PCNF. This study provides a novel strategy for transforming chitosan-based materials into state-of-the-art porous carbon nanofiber/zeolite self-N-doped composites, affording an efficient bioderived adsorbent for the removal of uremic toxins in patients with chronic kidney disease.falseChitosanN-doped porous carbon nanofibersN-doped zeolitesjournal article10.1016/j.ijbiomac.2023.1268802-s2.0-85171424591