Lee W.-C.HUEY-PEIR WUTONG-YUAN TAISHIH-PING LIUChen J.HONG-JENG YU2021-01-292021-01-2920040022-5347https://www.scopus.com/inward/record.uri?eid=2-s2.0-4143088230&doi=10.1097%2f01.ju.0000136255.83054.0c&partnerID=40&md5=8f5055f2c9af8ecf3458abf5b5db57efhttps://scholars.lib.ntu.edu.tw/handle/123456789/543899Purpose: We studied voiding behavior in women with type 2 diabetes vs nondiabetic female controls and examined factors associated with voiding dysfunction in patients with diabetes. Materials and Methods: After eliminating coexisting medical factors that could affect voiding function we evaluated voiding behaviors in 194 female patients with diabetes treated regularly at a diabetic clinic and 162 control women using a lower urinary tract symptom questionnaire based mainly on the American Urological Association Symptom Index questionnaire and free flow analyses with post-void residual urine estimates. Emptying efficiency was defined as 100% x volume voided/(volume voided + post-void residual urine). Results: Compared with controls patients with diabetes had significantly higher nocturia scores (p = 0.003), weaker urinary streams (p = 0.02), less voided volumes (220 ± 97 vs 280 ± 104 ml, p = 0.04) and lower maximal flow rates (19.4 ± 8.4 vs 25.9 ± 8.5 ml per second, p <0.001). Remarkable residual urine (100 ml or greater) was detected in 1.8% of controls vs 13.9% of patients. After controlling for age and voided volume diabetes was significantly associated with a decrease in baseline maximum flow of 4.5 ml per second (95% CI 2.9 to 6.2). In patients with diabetes peripheral neuropathy was an independent factor associated with the decrease in emptying efficiency (p = 0.03). Conclusions: Diabetes significantly altered voiding patterns in a significant proportion of women treated at the diabetic clinic. Peripheral neuropathy is an important factor associated with diabetic voiding dysfunction.[SDGs]SDG3adult; age; aged; article; bladder emptying; controlled study; diabetic neuropathy; disease association; female; human; major clinical study; medical society; micturition; micturition disorder; non insulin dependent diabetes mellitus; outpatient department; peripheral neuropathy; priority journal; questionnaire; symptom; urethrajournal article10.1097/01.ju.0000136255.83054.0c153110192-s2.0-4143088230