CHANG-FENG DAI2018-09-102018-09-102015http://www.scopus.com/inward/record.url?eid=2-s2.0-84930653674&partnerID=MN8TOARShttp://scholars.lib.ntu.edu.tw/handle/123456789/391674Four new eunicellin-type hirsutalins S-V (1-4), along with a known compound (-)-6α-hydroxy polyanthellin A (5), were isolated from the soft coral Cladiella hirsuta. The structures of the metabolites were determined by extensive spectroscopic analysis. Cytotoxity of compounds 1-5 against the proliferation of a limited panel of cancer cell lines was measured. Anti-inflammatory activity of compounds 1-5 was evaluated by measuring their ability in suppressing superoxide anion generation and elastase release in fMLP/CB-induced human neutrophils. ? 2015 by the authors; licensee MDPI.Anti-inflammatory activity; Cladiella hirsuta; Cytotoxic activity; Eunicellins; Soft coral[SDGs]SDG36 alpha hydroxypolyanthellin A; antineoplastic agent; diterpenoid; drug metabolite; elastase; hirsutalin s; hirsutalin t; hirsutalin u; hirsutalin v; superoxide; unclassified drug; antiinflammatory agent; diterpene; eunicellin; pancreatic elastase; antiinflammatory activity; antiproliferative activity; Article; Cladiella hirsuta; controlled study; coral; drug cytotoxicity; drug determination; drug isolation; drug screening; drug structure; human; human cell; animal; Anthozoa; cell proliferation; chemistry; drug effects; metabolism; neutrophil; Alcyonacea; Cladiella; Animals; Anthozoa; Anti-Inflammatory Agents; Cell Proliferation; Diterpenes; Humans; Neutrophils; Pancreatic Elastase; Superoxidesjournal article10.3390/md130527572-s2.0-84930653674WOS:000356241100011