HSIEN-HO LINChang H.-Y.Chiang Y.-T.MING-SHIANG WULin J.-T.WEI-CHIH LIAO2021-04-152021-04-1520140885-3177https://www.scopus.com/inward/record.uri?eid=2-s2.0-84914121965&doi=10.1097%2fMPA.0000000000000209&partnerID=40&md5=82b6d0127c423dcaf0a06a5bbf2ecd81https://scholars.lib.ntu.edu.tw/handle/123456789/556508Results: During 94,601 person-years of follow-up, 66 incident cases of pancreatitis occurred. Neither current nor ever smoking was associated with the incidence of pancreatitis (adjusted hazard ratio [aHR] 1.13; 95% confidence interval [CI], 0.62-2.06; and aHR, 1.14; 95% CI, 0.63-2.06, respectively). Dose-response analysis also showed no association between smoking and pancreatitis. By contrast, regular (aHR, 3.09; 95% CI, 1.51-6.30) and heavy alcohol drinking (aHR, 6.46; 95% CI, 3.07-13.60) were associated with an increased incidence of pancreatitis compared with abstinence.Conclusions: In this Asian population-based cohort, alcohol was associated with pancreatitis in a dose-dependent way, but smoking was not associated with pancreatitis. These results support for ethnic differences in susceptibility to smoking- and alcohol-related pancreatitis.Objectives: In Western population, smoking is a dose-dependent risk factor for pancreatitis, whereas a threshold of 5 drinks per day may exist for alcohol to increase pancreatitis risk. Given ethnic differences in tobacco and alcohol metabolism, we examined the associations between smoking, alcohol, and pancreatitis in Asians.Methods: A population-based cohort was assembled using participants of the National Health Interview Survey in Taiwan. Information on drinking and smoking was collected by in-person interview at baseline. Incident cases of pancreatitis were identified through data linkage with National Health Insurance claims database. Copyright ? 2014 by Lippincott Williams & Wilkins.[SDGs]SDG3acute disease; adult; aged; cholelithiasis; cohort analysis; comorbidity; dose response; drinking behavior; ethnology; female; follow up; health survey; human; incidence; male; middle aged; pancreatitis; Pancreatitis, Alcoholic; proportional hazards model; prospective study; risk factor; smoking; socioeconomics; Taiwan; Acute Disease; Adult; Aged; Alcohol Drinking; Cholelithiasis; Cohort Studies; Comorbidity; Dose-Response Relationship, Drug; Female; Follow-Up Studies; Health Surveys; Humans; Incidence; Male; Middle Aged; Pancreatitis; Pancreatitis, Alcoholic; Proportional Hazards Models; Prospective Studies; Risk Factors; Smoking; Socioeconomic Factors; Taiwanjournal article10.1097/MPA.0000000000000209250839982-s2.0-84914121965