2020-09-292024-05-18https://scholars.lib.ntu.edu.tw/handle/123456789/701314摘要：具有納米尺度且結構精確的3D分子的自組裝仍面臨著巨大的挑戰。而且，隨著構建基元數量的增加，這類分子的自組裝將變得更加困難。在我們之前的工作中，我們報導了基於一對自我識別的聯三&#21537;啶和Cd2+的混配錯合物。利用這種混配策略，我們成功構建了一系列巨大的超分子籠。為了進一步確認這些巨大超分子籠的結構信息，我們將采用Cryo-EM。Cryo-EM是一種生物大分子結構表徵技術，最近在近原子解析度的結構表徵上取得了飛躍發展。<br> Abstract: Self-assembly of nano-sized, well-defined 3D architectures is still in face of great challenge and is believed to become much more difficult with increasing the number of components. In our previous works, we reported a heteroleptic complexation based on a pair of self-recognition terpyridines and Cd2+. Utilizing heteroleptic complexation, we have constructed a series of huge supramolecular cages. In order to further visualize the structures of these huge supramolecular cages, we here want to employ cryo-EM, which was an expanding structural biology technique that has recently undergone a quantum leap progression in its near-atomic resolution.自組裝超分子冷凍電子顯微鏡self-assemblysupramoleculescryo-EM