Ho, Shang TseShang TseHoHsieh, Yueh TungYueh TungHsiehSHENG-YAO WANGMING-JU CHEN2022-07-292022-07-292019-03-0100220302https://scholars.lib.ntu.edu.tw/handle/123456789/616089The aim of this study was to evaluate the antiaging effect of a probiotic mixture using an in vivo mouse model in which aging was induced with D-galactose. Results of the Morris water maze test indicated that long-term administration of the probiotic mixture improved memory and learning abilities and ameliorated the apoptosis pattern in the hippocampus of aging mice treated with D-galactose. An antioxidation experiment indicated that administration of the probiotic mixture could restore activities of the antioxidant enzymes superoxide dismutase and catalase and inhibit the production of malondialdehyde. The antioxidant-related proteins nuclear factor erythroid 2-related factor 2 (Nrf2) and heme oxygenase-1 (HO-1) were upregulated in liver after treatment of D-galactose–treated aging mice with probiotics. Finally, the probiotic treatment did affect the production of short-chain fatty acids in D-galactose–treated aging mice. Our results highlighted a possible antioxidative effect triggered by short-chain fatty acids that contributed to improving the memory and learning abilities following treatment with the probiotic mixture and suggested that probiotics could serve as a therapy to modulate physiological function.enaging | antioxidant | probiotic mixture | reactive oxygen species (ROS)[SDGs]SDG3journal article10.3168/jds.2018-15811306390212-s2.0-85059671838WOS:000458518700002https://api.elsevier.com/content/abstract/scopus_id/85059671838