Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrier

Lai, Hsuan-JuHsuan-JuLaiDoan, Ha THa TDoanLin, Elliot YElliot YLinChiu, Yi-LingYi-LingChiuCheng, Yuan-KaiYuan-KaiChengLin, Yi-HeYi-HeLinHao-Sen Chiang2023-06-052023-06-052023-05-021078-0998https://scholars.lib.ntu.edu.tw/handle/123456789/631758Increased neutrophil extracellular trap (NET) formation and abundant NET-associated proteins are frequently found in the inflamed colon of patients with inflammatory bowel disease. Peptidyl arginine deiminase 4 (PAD4) activation is essential for the generation of NET and NET-mediated pathogenesis. However, the role of PAD4-dependent NET formation in murine inflammatory bowel disease models and the molecular mechanisms responsible for the altered gut barrier function are unknown.enadherens junctions; histones; intestinal barrier permeability; intestinal epithelial cells; neutrophil extracellular traps; peptidyl arginine deiminase 4; tight junctions[SDGs]SDG3[SDGs]SDG6Histones of Neutrophil Extracellular Traps Directly Disrupt the Permeability and Integrity of the Intestinal Epithelial Barrierjournal article10.1093/ibd/izac256366171752-s2.0-85159249553WOS:000908331400001https://api.elsevier.com/content/abstract/scopus_id/85159249553