Ren E.C.Kangueane P.Kolatkar P.Lin M.T.LI-HUI TSENGHansen J.A.2022-03-102022-03-1020000001-2815https://www.scopus.com/inward/record.uri?eid=2-s2.0-0033980451&doi=10.1034%2fj.1399-0039.2000.550104.x&partnerID=40&md5=6dc5b0330b99ac221d9e0dd323e11e41https://scholars.lib.ntu.edu.tw/handle/123456789/597141Mismatch of the minor histocompatibility antigen HA-1 has been shown to correlate with graft-versus-host disease in HLA-matched sibling marrow transplants. The HA-1(H) peptide (VLHDDLLEA) that generates this response is known to be presented by HLA-A*0201. In order to understand the interaction of HA-1 peptides with other HLA-A alleles, we have used the LOOK interface to construct molecular models of both HA-1(H) peptide (VLHDDLLEA) and HA-1(R) peptide (VLRDDLLEA) binding with 103 HLA-A alleles. The results show that in addition to A*0201, 21/103 other HLA-A alleles should be able to bind HA-1(H) peptide but not HA-1(R) peptide. Based on the modeled predictions, HLA alleles can be categorised into 4 groups with respect to their interaction with HA-1 peptides: Group 1 - bind HA-1(H) peptide but not HA-1(R) peptide; Group 2 - bind HA-1(R) peptide but not HA-1(H) peptide; Group 3 - bind both HA-1(H) and HA-1(R) peptides; Group 4 - bind neither peptide. These predicted binding patterns of HA-1 peptides will be useful as an aid for defining a wider pool of HLA-A alleles in which HA-1 disparities among donor-recipient pairs can be investigated.HA-1; HLA-A; Minor histocompatibility antigen; Molecular modeling; Peptides; Stem cell transplant[SDGs]SDG3HLA A antigen; minor histocompatibility antigen; allele; article; bone marrow transplantation; computer interface; device; graft versus host reaction; HLA matching; human; molecular model; priority journal; protein binding; Alleles; HLA-A Antigens; Humans; Minor Histocompatibility Antigens; Models, Molecular; Oligopeptidesjournal article10.1034/j.1399-0039.2000.550104.x107036042-s2.0-0033980451