研究成果


第 1 到 61 筆結果，共 61 筆。

公開日期標題作者來源出版物scopusWOS全文
12024Doxazosin inhibits vasculogenic mimicry in human non‑small cell lung cancer through inhibition of the VEGF‑A/VE‑cadherin/mTOR/MMP pathwayHsu, Jui-Ling; Leu, Wohn-Jenn; LIH-CHING HSU ; Hsieh, Chia-Hsun; JIH-HWA GUH Oncology letters
22024Cardenolide glycosides sensitize gefitinib-induced apoptosis in non-small cell lung cancer: inhibition of Na+/K+-ATPase serving as a switch-on mechanismDu, Chi-Min; Leu, Wohn-Jenn; Jiang, Yi-Huei; Chan, She-Hung; Chen, Ih-Sheng; Chang, Hsun-Shuo; LIH-CHING HSU ; Hsu, Jui-Ling; JIH-HWA GUH Naunyn-Schmiedeberg's archives of pharmacology
32024A novel HDAC6 inhibitor interferes microtubule dynamics and spindle assembly checkpoint and sensitizes cisplatin-induced apoptosis in castration-resistant prostate cancerYe, Pei-Chen; Leu, Wohn-Jenn; Yeh, Tsung-Yu; Hsu, Yu-Tung; Lin, Yi-Chin; Wei, Zi-Yuan; Chen, Yi-Chin; Chiang, Yi-Chang; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; JI-WANG CHERN ; CHAO-WU YU ; JIH-HWA GUH The Prostate
42023Mechanistic study of dual-function inhibitors targeting topoisomerase II and Rad51-mediated DNA repair pathway against castration-resistant prostate cancerChiang, Yi-Chang; Leu, Wohn-Jenn; Chen, Yi-Chin; Ye, Pei-Chen; Hsu, Yu-Tung; Hsiao, Yu-Chi; Hsu, Jui-Ling; Chan, She-Hung; LIH-CHING HSU ; Huang, Hsu-Shan; JIH-HWA GUH The Prostate
52023Design, Synthesis, and Evaluation of Glucose Transporter Inhibitor-SN38 Conjugates for Targeting Colorectal CancerChiu, Pei Fang; Chang, Chun Kai; Huang, Pin Shuo; Lin, You Yu; Lin, Chung Shun; Yang, Hui Yi; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry00
62023Anticancer Activity and Molecular Mechanisms of an Ursodeoxycholic Acid Methyl Ester-Dihydroartemisinin Hybrid via a Triazole Linkage in Hepatocellular Carcinoma CellsHsu, Ya-Fen; FAN-LU KUNG ; Huang, Tzu-En; Deng, Yi-Ning; JIH-HWA GUH ; Marchetti, Paolo; Marchesi, Elena; Perrone, Daniela; Navacchia, Maria Luisa; LIH-CHING HSU Molecules (Basel, Switzerland)33
72022Discovery of New Glucose Uptake Inhibitors as Potential Anticancer Agents by Non-Radioactive Cell-Based AssaysHung, Hsueh-Chih; Li, Li-Cheng; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU Molecules (Basel, Switzerland)31
82022The Combination of a Novel GLUT1 Inhibitor and Cisplatin Synergistically Inhibits Breast Cancer Cell Growth By Enhancing the DNA Damaging Effect and Modulating the Akt/mTOR and MAPK Signaling PathwaysWeng, Hao-Cheng; Sung, Chieh-Ju; Hsu, Jui-Ling; Leu, Wohn-Jenn; JIH-HWA GUH ; FAN-LU KUNG ; LIH-CHING HSU Frontiers in pharmacology96
92021Characterization of a fluorescent glucose derivative 1-NBDG and its application in the identification of natural SGLT1/2 inhibitorsKao, Ting-Yu; Wu, Hwa-Wei; SHOEI-SHENG LEE ; PI-HUI LIANG ; JIH-HWA GUH ; LIH-CHING HSU Journal of food and drug analysis32
102021Targeting Colorectal Cancer with Conjugates of a Glucose Transporter Inhibitor and 5-FluorouracilChang, Chun-Kai; Chiu, Pei-Fang; Yang, Hui-Yi; Juang, Yu-Pu; Lai, Yen-Hsun; Lin, Tzung-Sheng; LIH-CHING HSU ; LINDA CHIA-HUI YU ; PI-HUI LIANG Journal of Medicinal Chemistry16
112020Chalcones Display Anti-NLRP3 Inflammasome Activity in Macrophages through Inhibition of Both Priming and Activation Steps-Structure-Activity-Relationship and Mechanism StudiesLeu W.-J.; Chu J.-C.; Hsu J.-L.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Huang W.-J.; JIH-HWA GUH Molecules (Basel, Switzerland)88
122020Evaluation of the Anticancer Activity of a Bile Acid-Dihydroartemisinin Hybrid Ursodeoxycholic-Dihydroartemisinin in Hepatocellular Carcinoma CellsHuang T.-E.; Deng Y.-N.; Hsu J.-L.; Leu W.-J.; Marchesi E.; Capobianco M.L.; Marchetti P.; Navacchia M.L.; JIH-HWA GUH ; Perrone D.; LIH-CHING HSU Frontiers in Pharmacology1918
132020Phosphodiesterase Type 5 Inhibitors Synergize Vincristine in Killing Castration-Resistant Prostate Cancer Through Amplifying Mitotic Arrest SignalingHsu J.-L.; Leu W.-J.; LIH-CHING HSU ; Ho C.-H.; SHIH-PING LIU ; JIH-HWA GUH Frontiers in Oncology119
142020The (+)-brevipolide H displays anticancer activity against human castration-resistant prostate cancer: The role of oxidative stress and Akt/mTOR/p70S6K dependent pathways in G1 checkpoint arrest and apoptosisSheng Y.-H.; Leu W.-J.; Chen C.-N.; Hsu J.-L.; Liu Y.-T.; LIH-CHING HSU ; Hou D.-R.; JIH-HWA GUH Molecules44
152020Discovery of novel agents on spindle assembly checkpoint to sensitize vinorelbine-induced mitotic cell death against human non-small cell lung cancersChang Y.-C.; Tseng Y.-L.; Leu W.-J.; Du C.-M.; Jiang Y.-H.; LIH-CHING HSU ; Hsu J.-L.; Hou D.-R.; JIH-HWA GUH International Journal of Molecular Sciences21
162019Phosphodiesterase type 5 (PDE5) inhibitors sensitize topoisomerase II inhibitors in killing prostate cancer through PDE5-independent impairment of HR and NHEJ DNA repair systemsChang J.-F.; Hsu J.-L.; Sheng Y.-H.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Chan M.-L.; LIH-CHING HSU ; SHIH-PING LIU ; JIH-HWA GUH Frontiers in Oncology1113
172019The combination of MK-2206 and WZB117 exerts a synergistic cytotoxic effect against breast cancer cellsLi Y.-L.; Weng H.-C.; Hsu J.-L.; SHU-WHA LIN ; JIH-HWA GUH ; LIH-CHING HSU Frontiers in Pharmacology2422
182019Dihydroartemisinin–Bile Acid Hybridization as an Effective Approach to Enhance Dihydroartemisinin Anticancer ActivityMarchesi E.; Chinaglia N.; Capobianco M.L.; Marchetti P.; Huang T.-E.; Weng H.-C.; JIH-HWA GUH ; LIH-CHING HSU ; Perrone D.; Navacchia M.L.ChemMedChem1717
192018Para-toluenesulfonamide induces anti-tumor activity through Akt-dependent and -independent mTOR/p70S6K pathway: Roles of lipid raft and cholesterol contentsHsu J.-L.; Leu W.-J.; LIH-CHING HSU ; SHIH-PING LIU ; Zhong N.-S.; JIH-HWA GUH Frontiers in Pharmacology1019
202018Traversal of the Blood-Brain Barrier by Cleavable l -Lysine Conjugates of ApigeninWong T.-Y.; Tsai M.-S.; LIH-CHING HSU ; SHU-WHA LIN ; Liang P.-H.Journal of Agricultural and Food Chemistry66
212017Using precursor ion scan of 184 with liquid chromatography-electrospray ionization-tandem mass spectrometry for concentration normalization in cellular lipidomic studiesChao, Hsi-Chun; GUAN-YUAN CHEN ; LIH-CHING HSU ; Liao, Hsiao-Wei; Yang, Sin-Yu; Wang, San-Yuan; Li, Yu-Liang; SUNG-CHUN TANG ; YUFENG JANE TSENG ; CHING-HUA KUO 2221
222017Enantiomerically pure β-dipeptide derivative induces anticancer activity against human hormone-refractory prostate cancer through both PI3K/Akt-dependent and -independent pathwaysChan M.-L.; Yu C.-C.; Hsu J.-L.; Leu W.-J.; Chan S.-H.; LIH-CHING HSU ; SHIH-PING LIU ; Ivantcova P.M.; Dogan ?.; Br?se S.; Kudryavtsev K.V.; JIH-HWA GUH Oncotarget88
232016Downregulation of COMMD1 by MIR-205 promotes a positive feedback loop for amplifying inflammatory- and stemness-associated properties of cancer cellsYeh D.-W.; Chen Y.-S.; Lai C.-Y.; Liu Y.-L.; Lu C.-H.; Lo J.-F.; Chen L.; LIH-CHING HSU ; Luo Y.; Xiang R.; Chuang T.-H.Cell Death and Differentiation3434
242016Gain-of-function p53 mutant with 21-bp deletion confers susceptibility to multidrug resistance in MCF-7 cellsTsou S.-H.; Hou M.-H.; LIH-CHING HSU ; Chen T.-M.; YEN-HUI CHEN International Journal of Molecular Medicine1412
252016Non-immunosuppressive triazole-based small molecule induces anticancer activity against human hormone-refractory prostate cancers: The role in inhibition of PI3K/AKT/mTOR and c-Myc signaling pathwaysLeu W.-J.; Swain S.P.; Chan S.-H.; Hsu J.-L.; SHIH-PING LIU ; Chan M.-L.; Yu C.-C.; LIH-CHING HSU ; Chou Y.-L.; Chang W.-L.; Hou D.-R.; JIH-HWA GUH Oncotarget1414
262016Hemiasterlin derivative (R)(S)(S)-BF65 and Akt inhibitor MK-2206 synergistically inhibit SKOV3 ovarian cancer cell growthLai W.-T.; Cheng K.-L.; Baruchello R.; Rondanin R.; Marchetti P.; Simoni D.; Lee R.M.; JIH-HWA GUH ; LIH-CHING HSU Biochemical Pharmacology77
272016A novel hybrid drug between two potent anti-tubulin agents as a potential prolonged anticancer approachMarchetti P.; Pavan B.; Simoni D.; Baruchello R.; Rondanin R.; Mischiati C.; Feriotto G.; Ferraro L.; LIH-CHING HSU ; Lee R.M.; Dalpiaz A.European Journal of Pharmaceutical Sciences88
282015Effects of lipopolysaccharide on the expression of plasma membrane monoamine transporter (PMAT) at the blood-brain barrier and its implications to the transport of neurotoxinsWu, Kuo-Chen; Lu, Ya-Hsuan; Peng, Yi-Hsuan; LIH-CHING HSU ; CHUN-JUNG LIN Journal of Neurochemistry2315
292015Epi-reevesioside F inhibits Na+/K+-ATPase, causing cytosolic acidification, Bak activation and apoptosis in glioblastomaHsu J.-L.; Liu F.-L.; LIH-CHING HSU ; Chang H.-S.; Leu W.-J.; Yu C.-C.; Chang W.-L.; Chen I.-S.; FAN-LU KUNG ; JIH-HWA GUH Oncotarget65
302015Repurposing of phentolamine as a potential anticancer agent against human castration-resistant prostate cancer: A central role on microtubule stabilization and mitochondrial apoptosis pathwayHo C.-H.; Hsu J.-L.; SHIH-PING LIU ; LIH-CHING HSU ; Chang W.-L.; Chao C.C.-K.; JIH-HWA GUH Prostate1414
312015Repurposing of nitroxoline as a potential anticancer agent against human prostate cancer - A crucial role on AMPK/mTOR signaling pathway and the interplay with Chk2 activationChang W.-L.; LIH-CHING HSU ; Leu W.-J.; Chen C.-S.; JIH-HWA GUH Oncotarget3935
322015Zerumbone, a ginger sesquiterpene, induces apoptosis and autophagy in human hormone-refractory prostate cancers through tubulin binding and crosstalk between endoplasmic reticulum stress and mitochondrial insultChan M.-L.; Liang J.-W.; LIH-CHING HSU ; Chang W.-L.; SHOEI-SHENG LEE ; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology3933
332014The Akt inhibitor MK-2206 enhances the cytotoxicity of paclitaxel (Taxol) and cisplatin in ovarian cancer cellsLin Y.-H.; Chen B.Y.-H.; Lai W.-T.; Wu S.-F.; JIH-HWA GUH ; ANN-LII CHENG ; LIH-CHING HSU Naunyn-Schmiedeberg's Archives of Pharmacology3432
342014The K898E germline variant in the PP1-binding motif of BRCA1 causes defects in DNA RepairChen B.Y.-H.; Huang C.-H.; Lin Y.-H.; Huang C.-C.; Deng C.-X.; LIH-CHING HSU Scientific Reports89
352014Reevesioside A, a cardenolide glycoside, induces anticancer activity against human hormone-refractory prostate cancers through suppression of c-myc expression and induction of G1 arrest of the cell cycleLeu W.-J.; Chang H.-S.; Chan S.-H.; Hsu J.-L.; Yu C.-C.; LIH-CHING HSU ; Chen I.-S.; JIH-HWA GUH PLoS ONE2624
362014A unique amidoanthraquinone derivative displays antiproliferative activity against human hormone-refractory metastatic prostate cancers through activation of LKB1-AMPK-mTOR signaling pathwayHsu J.-L.; SHIH-PING LIU ; Lee C.-C.; LIH-CHING HSU ; Ho Y.-F.; Huang H.-S.; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology1312
372014Terfenadine induces anti-proliferative and apoptotic activities in human hormone-refractory prostate cancer through histamine receptor-independent Mcl-1 cleavage and Bak up-regulationWang W.-T.; Chen Y.-H.; Hsu J.-L.; Leu W.-J.; Yu C.-C.; Chan S.-H.; Ho Y.-F.; LIH-CHING HSU ; JIH-HWA GUH Naunyn-Schmiedeberg's Archives of Pharmacology2725
382013Synthesis and biological evaluation of novel C-aryl D-glucofuranosides as sodium-dependent glucose co-transporter 2 inhibitorsLin, Tzung-Sheng; Liw, Ya-Wen; Song, Jen-Shin; Hsieh, Tsung-Chih; Yeh, Hsien-Wei; LIH-CHING HSU ; CHUN-JUNG LIN ; Wu, Szu-Huei; PI-HUI LIANG Bioorganic and Medicinal Chemistry1311
392013Development of a novel non-radioactive cell-based method for the screening of SGLT1 and SGLT2 inhibitors using 1-NBDGChang, Hung-Chi; Yang, Su-Fu; Huang, Ching-Chun; Lin, Tzung-Sheng; PI-HUI LIANG ; CHUN-JUNG LIN ; LIH-CHING HSU Molecular BioSystems1716
402013Reevesioside F induces potent and efficient anti-proliferative and apoptotic activities through Na+/K+-ATPase α3 subunit-involved mitochondrial stress and amplification of caspase cascadesChan S.-H.; Leu W.-J.; LIH-CHING HSU ; Chang H.-S.; Hwang T.-L.; Chen I.-S.; Chen C.-S.; JIH-HWA GUH Biochemical Pharmacology1715
412013Ardisianone, a natural benzoquinone, efficiently induces apoptosis in human hormone-refractory prostate cancers through mitochondrial damage stress and survivin downregulationYu C.-C.; Wu P.-J.; Hsu J.-L.; Ho Y.-F.; LIH-CHING HSU ; Chang Y.-J.; Chang H.-S.; Chen I.-S.; JIH-HWA GUH Prostate2522
422012Development of hemiasterlin derivatives as potential anticancer agents that inhibit tubulin polymerization and synergize with a stilbene tubulin inhibitorLIH-CHING HSU ; Durrant D.E.; Huang C.-C.; Chi N.-W.; Baruchello R.; Rondanin R.; Rullo C.; Marchetti P.; Grisolia G.; Simoni D.; Lee R.M.Investigational New Drugs1410
432012Pim-1 knockdown potentiates paclitaxel-induced apoptosis in human hormone-refractory prostate cancers through inhibition of NHEJ DNA repairHsu J.-L.; Leong P.-K.; Ho Y.-F.; LIH-CHING HSU ; Lu P.-H.; Chen C.-S.; JIH-HWA GUH Cancer Letters2317
442012Rottlerin potentiates camptothecin-induced cytotoxicity in human hormone refractory prostate cancers through increased formation and stabilization of topoisomerase I-DNA cleavage complexes in a PKCδ-independent pathwayHsu J.-L.; Ho Y.-F.; TSAI-KUN LI ; Chen C.-S.; LIH-CHING HSU ; JIH-HWA GUH Biochemical Pharmacology1816
452008A PP1-binding motif present in BRCA1 plays a role in its DNA repair functionYu Y.-M.; Pace S.M.; Allen S.R.; Deng C.-X.; LIH-CHING HSU International Journal of Biological Sciences2423
462007Coordinate up-regulation of TMEM97 and cholesterol biosynthesis genes in normal ovarian surface epithelial cells treated with progesterone: Implications for pathogenesis of ovarian cancerWilcox C.B.; Feddes G.O.; Willett-Brozick J.E.; LIH-CHING HSU ; DeLoia J.A.; Baysal B.E.BMC Cancer4140
472007Identification and functional characterization of a PP1-binding site in BRCA1LIH-CHING HSU Biochemical and Biophysical Research Communications1616
482007Loss of distal 11q is associated with DNA repair deficiency and reduced sensitivity to ionizing radiation in head and neck squamous cell carcinomaParikh R.A.; White J.S.; Huang X.; Schoppy D.W.; Baysal B.E.; Baskaran R.; Bakkenist C.J.; Saunders W.S.; LIH-CHING HSU ; Romkes M.; Gollin S.M.Genes Chromosomes and Cancer7265
492006Gene amplification and overexpression of protein phosphatase 1α in oral squamous cell carcinoma cell linesLIH-CHING HSU ; Huang X.; Seasholtz S.; Potter D.M.; Gollin S.M.Oncogene3937
502005Centrosome abnormalities in ovarian cancerLIH-CHING HSU ; Kapali M.; DeLoia J.A.; Gallion H.H.International Journal of Cancer4442
512004The HPV16 E6/E7 oncogene sensitizes human ovarian surface epithelial cells to low-dose but not high-dose 5-FU and 5-FUdRLIH-CHING HSU ; Lee R.M.; White R.L.Biochemical and Biophysical Research Communications44
522002Regulation of BRCA1 phosphorylation by interaction with protein phosphatase 1αLiu Y.; Virshup D.M.; White R.L.; LIH-CHING HSU Cancer Research3130
532001Identification of a γ-tubulin-binding domain in BRCA1LIH-CHING HSU ; Doan T.P.; White R.L.Cancer Research116109
541998Mapping of 55 new rat microsatellite markers from chromosome-specific librariesShepel L.A.; Lan H.; Brasic G.M.; Gheen M.E.; LIH-CHING HSU ; Haag J.D.; Gould M.N.Mammalian Genome168
551998BRCA1 is associated with the centrosome during mitosisLIH-CHING HSU ; White R.L.Proceedings of the National Academy of Sciences of the United States of America274271
561996Allelic imbalance in mammary carcinomas induced by either 7,12-dimethylbenz[a]anthracene or ionizing radiation in rats carrying genes conferring differential susceptibilities to mammary carcinogenesisHaag J.D.; LIH-CHING HSU ; Newton M.A.; Gould M.N.Molecular Carcinogenesis31
571994Genetic Identification of Mcs-1, a Rat Mammary Carcinoma Suppressor GeneLIH-CHING HSU ; Kennan W.S.; Shepel L.A.; Jacob H.J.; Szpirer C.; Szpirer J.; Lander E.S.; Gould M.N.Cancer Research6056
581994Bivariate flow karyotyping, sorting, and peak assignment of all rat chromosomesShepel L.A.; Morrissey L.W.; LIH-CHING HSU ; Gould M.N.Genomics2120
591993Cloning and Characterization of Overexpressed Genes in the Mammary Gland of Rat Strains Carrying the Mammary CarcinomaSuppressor (Mcs) GeneLIH-CHING HSU ; Gould M.N.Cancer Research1313
601991Molecular cloning of copenhagen rat krev-1 and rap1b cdnas and study of their association with mammary tumor resistance in the copenhagen ratLIH-CHING HSU ; Gould M.N.Carcinogenesis13
611990Molecular cloning of rat krev-1 cdna and analysis of the mrna levels in normal and nmu-induced mammary carcinomasHong H.J.; LIH-CHING HSU ; Gould M.N.Carcinogenesis69