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aldosterone; collagen; collagen 1a1; eplerenone; glucocorticoid receptor; immunoglobulin enhancer binding protein; interstitial collagenase; messenger rna; mifepristone; phosphatidylinositol 3 kinase; protein kinase b; small interfering rna; tissue inhibitor of metalloproteinase 1; unclassified drug; aldosterone; collagen; interstitial collagenase; messenger rna; timp1 protein, human; tissue inhibitor of metalloproteinase 1; adult; aldosterone urine level; animal experiment; article; bioaccumulation; collagen synthesis; controlled study; diastolic dysfunction; enzyme blood level; enzyme release; female; gene expression; heart fibroblast; heart left ventricle function; heart left ventricle mass; heart muscle fibrosis; human; human cell; in vitro study; in vivo study; major clinical study; male; middle aged; mouse; nonhuman; primary hyperaldosteronism; priority journal; protein expression; transthoracic echocardiography; analysis of variance; animal; c57bl mouse; cardiac muscle; cytology; disease model; fibroblast; fibrosis; gene expression regulation; genetics; hyperaldosteronism; immunohistochemistry; knockout mouse; metabolism; needle biopsy; pathology; pathophysiology; procedures; randomization; real time polymerase chain reaction; signal transduction; western blotting; aldosterone; analysis of variance; animals; biopsy, needle; blotting, western; collagen; disease models, animal; female; fibroblasts; fibrosis; gene expression regulation; humans; hyperaldosteronism; immunohistochemistry; male; matrix metalloproteinase 1; mice; mice, inbred c57bl; mice, knockout; myocardium; random allocation; real-time polymerase chain reaction; rna, messenger; signal transduction; tissue inhibitor of metalloproteinase-1
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