https://scholars.lib.ntu.edu.tw/handle/123456789/112710
標題: | ASSOCIATION OF POLYMORPHISMS IN NR1I 2 AND ABCB1 GENES WITH EPILEPSY TREATMENT RESPONSES | 作者: | Hung, Chin-Chuan Tai, John Jen Kao, Pi-Ju Lin, Min-Shung Liou, Horng-Huei |
關鍵字: | ABCB1;drug;response;intractable epilepsy;multidrug resistance;pharmacogenetics;PXR | 公開日期: | 2007 | 卷: | v.8 | 期: | n.9 | 起(迄)頁: | 1151-1158 | 來源出版物: | PHARMACOGENOMICS | 摘要: | Objectives: The aim of this study was to investigate whether the polymorphisms in the NR112 and ABCB1 genes were associated with epilepsy treatment responses. Methods & results: NR112 and ABCB1 polymorphisms were genotyped in 114 drug-resistant epileptic patients, 213 seizure-free patients and 287 normal controls. Highly specific real-time PCR was applied to detect the variants by using TaqMan allelic specific probe. For a single gene test, it was demonstrated that 3435C>T in the ABCB1 gene had a significant effect on epilepsy treatment responses, but polymorphisms in the NR112 gene did not. Further analysis using a logistic regression model revealed that only 2677G>T and 3435C>T in the ABCB1 gene and their interaction term were associated with drug-resistant epilepsy after adjustment for etiology and epilepsy classification. In the present study, the polymorphisms in the NR112 gene were not significantly associated with epilepsy treatment responses. Conclusion: Our results indicated that 2677G>T and 3435C > T in the ABCB1 gene contributed to drug-resistant epilepsy. Although biologically plausible, the polymorphisms in NR112 investigated in the present study did not play a role in epilepsy treatment responses. Other unveiled genetic variants in the NR112 gene that may have the potential to affect ABCB1 gene expression are worth further investigation in future studies. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/83969 |
顯示於: | 流行病學與預防醫學研究所 |
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