https://scholars.lib.ntu.edu.tw/handle/123456789/139213
標題: | Wild bitter gourd extract up-regulates mRNA expression of PPAR alpha, PPAR gamma and their target genes in C57BL/6J mice | 作者: | Chao, Che-Yi Yin, Mei-Chin Huang, Ching-jang |
關鍵字: | Adiponectin; PPARα; PPARγ; Wild bitter gourd | 公開日期: | 2011 | 卷: | 135 | 期: | 1 | 起(迄)頁: | 156-161 | 來源出版物: | JOURNAL OF ETHNOPHARMACOLOGY | 摘要: | Ethnopharmacological relevance: Wild bitter gourd (Momordica charantia Linn. var. abbreviata ser.) was commonly used as a medicinal herb in Asia, Africa, and South America because of its anti-diabetic, antibacterial, anti-viral, and chemopreventive functions. Materials and methods: C57BL/6J mice were orally administered with 250, 500 or 1000 mg/kg BW of WBGE in 0.2 mL/mouse of olive oil daily for 2 weeks. Results: Compared to control (vehicle treated) mice, mice receiving WBGE showed significantly higher PPARα, ACO (acyl-CoA oxidase) and L-FABP (liver-fatty acid binding protein) mRNA expression, ACO activity and protein in the liver (P < 0.05), as clofibrate-treated mice. WBGE treatment also resulted in significantly higher PPARγ and LPL (lipoprotein lipase) mRNA (P < 0.05) in the epididymal adipose tissue. Liver triglyceride and non-esterified fatty acid concentration in WBGE treated mice were significantly lower than those of control mice (P < 0.05). Plasma adiponectin level was significantly higher in mice receiving WBGE than in control mice (P < 0.05), as the rosiglitazone treated mice. Conclusion: Results of this study demonstrated that WBGE also activates PPARα and PPARγ signaling pathway in vivo. ? 2011 Elsevier Ireland Ltd. All rights reserved. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/243119 | DOI: | 10.1016/j.jep.2011.03.001 | SDG/關鍵字: | acyl coenzyme A oxidase; adiponectin; antidiabetic agent; binding protein; clofibrate; fatty acid; lipoprotein lipase; liver enzyme; liver fatty acid binding protein; messenger RNA; Momordica charantia extract; olive oil; peroxisome proliferator activated receptor alpha; peroxisome proliferator activated receptor gamma; rosiglitazone; triacylglycerol; unclassified drug; animal experiment; animal tissue; article; blood sampling; body weight; C57BL 6 mouse; concentration (parameters); controlled study; diet supplementation; epididymis fat; gene expression; gene targeting; in vivo study; male; metabolic disorder; Momordica charantia; mouse; nonhuman; reverse transcription polymerase chain reaction; signal transduction; upregulation; Western blotting; Acyl-CoA Oxidase; Adiponectin; Adipose Tissue; Animals; Clofibrate; Epididymis; Fatty Acid-Binding Proteins; Fatty Acids, Nonesterified; Fruit; Gene Expression; Hypoglycemic Agents; Hypolipidemic Agents; Lipoprotein Lipase; Liver; Male; Mice; Mice, Inbred C57BL; Momordica charantia; Plant Extracts; PPAR alpha; PPAR gamma; RNA, Messenger; Thiazolidinediones; Triglycerides; Up-Regulation; Abbreviata; Momordica charantia; Mus |
顯示於: | 生化科技學系 |
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