https://scholars.lib.ntu.edu.tw/handle/123456789/146121
Title: | Antimicrobial Susceptibilities among Clinical Isolates of Extended- Spectrum Cephalosporin-Resistant Gram-Negative Bacteria in a Taiwanese University Hospital | Authors: | TENG, LEE-JENE HO, SHEN-WU |
Keywords: | BETA-LACTAM RESISTANCE;ACINETOBACTER-BAUMANNII;PSEUDOMONAS- AERUGINOSA;NOSOCOMIAL INFECTIONS;CIPROFLOXACIN;SURVEILLANCE | Issue Date: | 2002 | Journal Volume: | v.49 | Journal Issue: | n.1 | Start page/Pages: | 69-76 | Source: | JOURNAL OF ANTIMICROBIAL CHEMOTHERAPY | Abstract: | Infections caused by Gram-negative bacteria with resistance to extended- spectrum cephalosporins require the identification of effective alternative antimicrobial therapy. To determine the role of other pre- existing or currently available antimicrobial agents in treating infections caused by these multidrug-resistant pathogens, we evaluated the in vitro susceptibilities of these agents in 411 non-duplicate isolates of extended-spectrum cephalosporin-resistant Gram-negative bacteria recovered between January 1999 and December 1999 in a major teaching hospital in Taipei, Taiwan. These isolates included cefotaxime-resistant ( MICs greater than or equal to 2 mg/L) Escherichia coli (66 isolates) and Klebsiella pneumoniae (77 isolates); cefotaxime-resistant (MICs greater than or equal to 64 mg/L) Enterobacter cloacae (59 isolates), Serratia marcescens (52 isolates) and Citrobacter freundii (52 isolates); and ceftazidime-resistant (MICs greater than or equal to 64 mg/L) Pseudomonas aeruginosa (50 isolates) and Acinetobacter baumannii (55 isolates). Overall, carbapenems( imipenem and meropenem) had good activity against the cefotaxime-resistant Enterobacteriaceae tested (>90% of isolates were susceptible). However, carbapenems had limited activity against the ceftazidime-resistant P. aeruginosa ( only 4% of isolates were susceptible ) and A. baumannii (51- 56% of isolates were susceptible). Among the E. coli and K. pneumoniae isolates tested, 33.3% and 58.4%, respectively, exhibited extended-spectrum beta-lactamase phenotype, determined by the double disc method. Over 80% of cefotaxime -resistant E. cloacae and C. freundii were susceptible to cefepime, but this agent had limited activity against other bacteria tested. Susceptibilities of these isolates to ciprofloxacin varied, ranging from 25% for A. baumannii to 92% for E. cloacae. Newer fluoroquinolones (moxifloxacin and trovafloxacin) had equal or less activity against these organisms, except for A. baumannii for which their MIC(90)s( 8-16 mg/L) were four- to 16-fold less than that of ciprofloxacin (MIC90 128 mg/L). |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/105276 |
Appears in Collections: | 醫學檢驗暨生物技術學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.