https://scholars.lib.ntu.edu.tw/handle/123456789/194293
標題: | Efficacy and Safety of a Live Attenuated, Cold-Adapted Influenza Vaccine, Trivalent against Culture-Confirmed Influenza in Young Children in Asia | 作者: | Tam, John S. Capeding, Maria Rosario Z. Lum, Lucy Chai See Chotpitayasunondh, Tawee Jiang, Zaifang Huang, Li-Min |
關鍵字: | influenza;vaccine;live-attenuated;children | 公開日期: | 2007 | 卷: | v.26 | 期: | n.7 | 起(迄)頁: | 619-628 | 來源出版物: | PEDIATRIC INFECTIOUS DISEASE JOURNAL | 摘要: | Background: This study was designed to evaluate the efficacy and safety of cold-adapted influenza vaccine, trivalent ( CAIV-T) against culture- confirmed influenza in children 12 to <36 months of age during 2 consecutive influenza seasons at multiple sites in Asia. Methods: In year 1, 3 174 children 12 to <36 months of age were randomized to receive 2 doses of CAIV-T (n = 1900) or placebo (n = 1274) intranasally >= 28 days apart. In year 2, 2947 subjects were rerandomized to receive I dose of CAIV-T or placebo. Results: Mean age at enrollment was 23.5 +/- 7.4 months . In year 1, efficacy of CAIV-T compared with placebo was 72.9% [ 95% confidence interval (CI): 62.8-80.5%] against antigenically similar influenza subtypes, and 70.1% (95% CI: 60.9-77.3%) against any strain. In year 2, revaccination with CATV-T demonstrated significant efficacy against antigenically similar (84.3%; 95% CI: 70.192.4%) and any (64 .2%; 95% CI: 44.2-77.3%) influenza strains. In year 1, fever , runny nose/nasal congestion, decreased activity and appetite, and use of fever medication were more frequent with CAIV-T after dose 1. Runny nose/nasal congestion after dose 2 (year 1) and dose 3 (year 2) and use of fever medication after dose 3 (year 2) were the only other events reported significantly more frequently in CAIV-T recipients. Conclusions: CAIV-T was well tolerated and effective in preventing culture-confirmed influenza illness over multiple and complex influenza seasons in young children in Asia. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88577 |
顯示於: | 醫學系 |
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