https://scholars.lib.ntu.edu.tw/handle/123456789/194317
標題: | Safety and Immunogenicity of a Diphtheria, Tetanus, and Acellular Pertussis-Inactivated Poliovirus Vaccine/Haemophilus Influenzae Type B Combination Vaccine Administered to Taiwanese Infants At | 作者: | LIN, TZOU-YIEN CHANG, LUAN-YIN |
公開日期: | 2003 | 卷: | v.26 | 期: | n.5 | 起(迄)頁: | 315-322 | 來源出版物: | CHANG GUNG MEDICAL JOURNAL | 摘要: | BACKGROUND: Combined vaccines are urgently needed to ensure compliance with the increasing number of recommended vaccines for children. We evaluated the safety and antibody response to a diphtheria, tetanus, and acellular pertussis- inactivated poliovirus vaccine/Haemophilus influenzae type b (DTaP-IPV/Hib) combination vaccine administrated to infants at 2, 4, and 6 months of age. METHODS: Sixty healthy infants between 6 and 12 weeks of age were enrolled. One group of vaccines received the DTaP-IPV/ Hib in a single injection, while another group concurrently received DTaP- IPV and Hib at separate injection sites. Solicited adverse events were monitored by parental observation and were recorded on a diary card. Levels of serum antibodies to DTaP and polyribosyl-ribitolphosphate- tetanus (PRP-T) antigens were collected before the first vaccine dose and 1 month after the third vaccine dose. RESULTS: The combined- injection group tended to have lower local reactions, and there was no increase in reactogenicity when compared with the separate- injection group. Seroconversion rates were 100% in both groups for all antigens, except for the anti-polio 2 antibody in the combined-injection group (96.4%). The combined-injection group had lower antibody levels of PRP (8 .45 microg/ml ) than did the separate-injection group (20.61 microg/ml). However, the percentage of vaccines achieving protective levels of antibody to PRP (> or = 0.15 microg/ml or > or = 1.0 microg/ml) was similar in both groups. CONCLUSIONS: DTaP-IPV/Hib may be safely and effectively administered to healthy infants, using a 2-, 4-, and 6-month vaccination schedule. This combined vaccine is cost- effective, more acceptable to parents and physicians, and minimizes distress to infants. |
URI: | http://ntur.lib.ntu.edu.tw//handle/246246/88605 |
顯示於: | 醫學系 |
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