https://scholars.lib.ntu.edu.tw/handle/123456789/329327
標題: | Evidence that a regulatory gene autoregulates splicing of its transcript. | 作者: | Zachar, Zuzana TZE-BIN CHOU Bingham, Paul M. |
公開日期: | 1987 | 卷: | 6 | 期: | 13 | 起(迄)頁: | 4105 - 4111 | 來源出版物: | The EMBO Journal | 摘要: | Expression of the presumptive regulatory gene, suppressor-of-white-apricot [su(wa)], is controlled at the level of splicing. Results reported here indicate that this control represents autorepression of su(wa) expression. Specifically, reverse genetic studies demonstrate that the 3.5 kb mature su(wa) RNA (produced by removal of seven introns) is a message essential for su(wa)+ function and indicate that the abundant 4.4 kb and 5.2 kb mature su(wa) RNAs (resulting when the first or first and second of the seven introns are not removed) are, unexpectedly, byproducts of repression of production of the functional 3.5 kb RNA. Moreover, several experiments indicate that this repression of splices necessary to produce the 3.5 kb RNA is dependent on the translation product of the 3.5 kb RNA itself. We propose that this regulatory gene autoregulates its expression by controlling splicing of its primary transcript. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-0023661345&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/329327 |
ISSN: | 02614189 | SDG/關鍵字: | animal; article; Drosophila; gene repression; genetic transcription; genetics; homeostasis; molecular cloning; mutation; protein synthesis; regulator gene; RNA splicing; Animals; Cloning, Molecular; Drosophila; Genes, Regulator; Homeostasis; Mutation; Protein Biosynthesis; RNA Splicing; Suppression, Genetic; Transcription, Genetic; MLCS; MLOWN |
顯示於: | 分子與細胞生物學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。