https://scholars.lib.ntu.edu.tw/handle/123456789/340650
標題: | Self-contained, biomolecular motor-driven protein sorting and concentrating in an ultrasensitive microfluidic chip | 作者: | CHIH-TING LIN Kao, Ming-Tse Kurabayashi, Katsuo Meyhofer, Edgar |
公開日期: | 2008 | 卷: | 8 | 期: | 4 | 起(迄)頁: | 1041-1046 | 來源出版物: | Nano Letters | 摘要: | We developed a molecular sorter that operates without external power or control by integrating the microtubule-based, biological motor klnesin into a microfluidic channel network to sort, transport, and concentrate molecules. In our devices, functlonalized microtubules that capture analyte molecules are steered along kinesin-coated microchannel tracks toward a collector structure, concentrated, and trapped. Using fluorescent analyte molecules and nanoliter sample volumes, we demonstrated 14 fM sensitivity, even In the presence of high concentrations of other proteins. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-44449115225&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/340650 |
DOI: | 10.1021/nl072742x |
顯示於: | 電子工程學研究所 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。