https://scholars.lib.ntu.edu.tw/handle/123456789/356023
標題: | Photoassisted Synthesis of Luminescent Mannose-Au Nanodots for the Detection of Thyroglobulin in Serum | 作者: | Huang, Chih-Ching Hung, Yu-Lun Shiang, Yen-Chun Lin, Tai-Yuan Lin, Yu-Shen CHAO-TSEN CHEN HUAN-TSUNG CHANG |
關鍵字: | Cancer; Glycoproteins; Luminescence; Nanoparticles; Sensitive and selective assay for Tg. Gold | 公開日期: | 2010 | 卷: | 5 | 期: | 2 | 起(迄)頁: | 334-341 | 來源出版物: | Chemistry - An Asian Journal | 摘要: | We have employed mannosemodified gold nanodots (Man-Au NDs) as a luminescence sensor for the detection of the thyroid-cancer marker thyroglobulin (Tg) in homogeneous solutions. The luminescent Man-Au NDs are prepared through the reaction of 2.9 nm-diameter gold nanoparticles (Au NPs) with 11-mercapto-3,6,9-trioxaundecyl-a-d-mannopyranoside (Man-RSH) under the irradiation of a lightemitting diode (LED). We have found that the irradiation enhances the quantum yield (~11%), alters the emission wavelength and lifetimes, and shortens the preparation time. A luminescence assay has been developed for Tg based on the competition between Tg and Man-Au NDs for the interaction with the concanavalin A (Con A). Because luminescence quenching of the Man-Au NDs by Con A is inhibited by Tg selectivity, we have obtained a highly sensitive and selective assay for Tg. ? 2010 Wiley-VCH Verlag GmbH&Co. KGaA, Weinheim. |
URI: | http://scholars.lib.ntu.edu.tw/handle/123456789/356023 | DOI: | 10.1002/asia.200900346 | SDG/關鍵字: | Cancer; Cancer markers; Concanavalin A; Emission wavelength; Gold nanodots; Gold nanoparticle; Highly sensitive; Homogeneous solutions; Luminescence assay; Luminescence quenching; Luminescence sensor; Nanodots; Photoassisted synthesis; Sensitive and selective assay for Tg. Gold; Thyroglobulin; Chemical sensors; Glycoproteins; Irradiation; Luminescence; Nanoparticles; Proteins; Synthesis (chemical); Gold; concanavalin A; fluorescent dye; gold; mannose; metal nanoparticle; thyroglobulin; article; blood; chemistry; genetic procedures; human; luminescence; photochemistry; Biosensing Techniques; Concanavalin A; Fluorescent Dyes; Gold; Humans; Luminescent Measurements; Mannose; Metal Nanoparticles; Photochemistry; Thyroglobulin |
顯示於: | 化學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。