https://scholars.lib.ntu.edu.tw/handle/123456789/360495
標題: | Deferasirox in iron-overloaded patients with transfusion-dependent myelodysplastic syndromes: Results from the large 1-year EPIC study | 作者: | KAI-HSIN LIN | 關鍵字: | Deferasirox; Iron chelation therapy; Labile plasma iron; Myelodysplastic syndromes; Serum ferritin | 公開日期: | 2010 | 卷: | 34 | 期: | 9 | 起(迄)頁: | 1143-1150 | 來源出版物: | Leukemia Research | 摘要: | The prospective 1-year EPIC study enrolled 341 patients with myelodysplastic syndromes (MDS); although baseline iron burden was >2500. ng/mL, ?50% were chelation-na?ve. Overall median serum ferritin decreased significantly at 1 year (p=0.002). Decreases occurred irrespective of whether patients were chelation-na?ve or previously chelated; changes were dependent on dose adjustments and ongoing iron intake. Sustained reductions in labile plasma iron were observed. Discontinuation rate (48.7%) and adverse event profile were consistent with previously reported deferasirox data in MDS. Alanine aminotransferase levels decreased significantly; change correlated significantly with reduction in serum ferritin (p<0.0001). This large dataset prospectively confirms the efficacy and well characterizes the safety profile of deferasirox in MDS. ? 2010 Elsevier Ltd. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-77955268192&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/360495 |
DOI: | 10.1016/j.leukres.2010.03.009 | SDG/關鍵字: | alanine aminotransferase; deferasirox; ferritin; iron; abdominal pain; adolescent; adult; aged; anemia; article; chelation therapy; child; clinical trial; colitis; constipation; creatinine blood level; cytopenia; dementia; diarrhea; dose response; drug dose increase; drug dose reduction; drug efficacy; drug fatality; drug induced headache; drug safety; drug withdrawal; duodenitis; erythrocyte transfusion; esophagitis; female; ferritin blood level; fever; gastritis; gastrointestinal symptom; hearing impairment; heart failure; human; hyperthermia; iron blood level; iron intake; iron overload; leukocyte count; major clinical study; male; multicenter study; myelodysplastic syndrome; neutropenia; pancytopenia; preschool child; priority journal; prospective study; rash; school child; side effect; thrombocytopenia; upper abdominal pain; vomiting; weight reduction |
顯示於: | 醫學系 |
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