https://scholars.lib.ntu.edu.tw/handle/123456789/369998
標題: | High-speed mass measurement of nanoparticle and virus | 作者: | RICHIE CHEN | 公開日期: | 2012 | 卷: | 84 | 期: | 11 | 起(迄)頁: | 4965-4969 | 來源出版物: | Analytical Chemistry | 摘要: | Until now, there have been no relatively easy methods to measure the mass and mass distributions of nanoparticles/viruses. In this work, we report the first set of measurements of mass and mass distributions for nanoparticles/viruses using a novel mass spectrometry technology. In the past, mass spectrometry was typically used to measure the mass of a particle or molecule with a mass less than 1 000 000 Da. We developed cell mass spectrometry that can measure the mass of a cell or a microparticle. Nevertheless, there is a gap for mass measurement methods in the mass region of a nanoparticle or virus (1 MDa to 1 GDa). Here, we developed a nanoparticle/virus mass spectrometry technique to make rapid and accurate mass and mass distribution measurements of nanoparticles/viruses. This technique should be valuable for the quality control of nanoparticle production and the identification of various viruses. In the future, this method can also serve to monitor drug delivery when nanoparticles are used as carriers. Furthermore, it may be possible to measure the degree of infection by measuring the number of viruses in specific cells or in plasma. ? 2012 American Chemical Society. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84861852217&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/369998 |
DOI: | 10.1021/ac300615v | SDG/關鍵字: | Accurate mass; Cell mass; High-speed; Mass distribution; Mass measurements; Mass regions; Micro particles; Nano-particle production; Spectrometry technique; Drug delivery; Mass spectrometry; Viruses; Nanoparticles; nanoparticle; polystyrene derivative; article; chemistry; human; Human immunodeficiency virus; instrumentation; mass spectrometry; methodology; molecular weight; nanotechnology; particle size; time; HIV; Humans; Mass Spectrometry; Molecular Weight; Nanoparticles; Nanotechnology; Particle Size; Polystyrenes; Time Factors |
顯示於: | 生物機電工程學系 |
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