https://scholars.lib.ntu.edu.tw/handle/123456789/370289
標題: | Discovery of biomarkers for gastric cancer: a proteomics approach | 作者: | Lin, Li-Ling Huang, Hsuan-Cheng Juan, Hsueh-Fen |
關鍵字: | Biomarker; Gastric cancer; Mass spectrometry; Proteomics | 公開日期: | 六月-2012 | 出版社: | Elsevier B.V. | 卷: | 75 | 期: | 11 | 起(迄)頁: | 3081-3097 | 來源出版物: | Journal of Proteomics | 摘要: | Gastric cancer is the second leading cause of cancer-related deaths worldwide. Although many treatment options exist for patients with gastric tumors, the incidence and mortality rate of gastric cancer are on the rise. The early stages of gastric cancer are non-symptomatic, and the treatment response is unpredictable. This situation is further aggravated by a lack of diagnostic biomarkers that can aid in the early detection and prognosis of gastric cancer and in the prediction of chemoresistance. Moreover, clinical surgical specimens are rarely obtained, and traditional biomarkers of gastric cancer are not very effective. Many studies in the field of proteomics have contributed to the discovery and establishment of powerful diagnostic tools (e.g., ProteinChip array) in the management of cancer. The evolution in proteomic technologies has not only enabled the screening of a large number of samples but also enabled the identification of pathologically significant proteins, such as phosphoproteins, and the quantitation of difference in protein expression under different conditions. Multiplexed assays are used widely to accurately fractionate various complex samples such as blood, tissue, cells, and Helicobacter pylori-infected specimens to identify differentially expressed proteins. Biomarker detection studies have substantially contributed to the areas of secretome, metabolome, and phosphoproteome. Here, we review the development of potential biomarkers in the natural history of gastric cancer, with specific emphasis on the characteristics of target protein convergence. ? 2012 Elsevier B.V. |
URI: | http://europepmc.org/abstract/med/22498886 http://scholars.lib.ntu.edu.tw/handle/123456789/370289 |
DOI: | 10.1016/j.jprot.2012.03.046 | SDG/關鍵字: | 5 (2,6 dichlorobenzylsulfonyl) 3 [3,5 dimethyl 4 [2 (1 pyrrolidinylmethyl) 1 pyrrolidinylcarbonyl] 1h pyrrol 2 ylmethylene] 1,3 dihydro 2h indol 2 one; apolipoprotein A1; apolipoprotein C1; apolipoprotein C3; CA 19-9 antigen; cathepsin B; cisplatin; daunorubicin; diallyl trisulfide; doxorubicin; galectin 2; lactate dehydrogenase; pyruvate dehydrogenase; retinoic acid; vincristine; antineoplastic activity; blood; cancer cell culture; cancer diagnosis; cells; diagnostic accuracy; enzyme linked immunosorbent assay; Helicobacter infection; Helicobacter pylori; human; lactate dehydrogenase blood level; liquid chromatography; mass spectrometry; matrix assisted laser desorption ionization time of flight mass spectrometry; microarray analysis; nonhuman; priority journal; prognosis; protein expression; proteomics; quantitative analysis; review; sensitivity and specificity; stomach cancer; stomach juice; tissues; Animals; Gene Expression Regulation, Neoplastic; Humans; Neoplasm Proteins; Protein Array Analysis; Proteomics; Stomach Neoplasms; Tumor Markers, Biological; Helicobacter pylori |
顯示於: | 生命科學系 |
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