https://scholars.lib.ntu.edu.tw/handle/123456789/370386
Title: | Analyzer-based phase-contrast x-ray imaging of carotid plaque microstructure | Authors: | Appel, Alyssa A. CHENG-YING CHOU Greisler, Howard P. Larson, Jeffery C. Vasireddi, Sunil Zhong, Zhong Anastasio, Mark A. Brey, Eric M. |
Keywords: | Cardiovascular imaging; Carotid stenosis; Computerized tomography; Phase contrast X-ray imaging | Issue Date: | 2012 | Journal Volume: | 204 | Journal Issue: | 5 | Start page/Pages: | 631-636 | Source: | American Journal of Surgery | Abstract: | Background: Plaque vulnerability depends, in part, on composition. Imaging techniques are needed that can aid the prediction of plaque stability. High-contrast images of soft-tissue structure have been obtained with x-ray phase-contrast (PC) imaging. This research investigates multiple image radiography (MIR), an x-ray PC imaging technique, for evaluation of human carotid artery plaques. Methods: Carotid plaques were imaged with ultrasound and subsequently excised and formalin fixed. MIR imaging was performed. By using synchrotron radiation, conventional radiographs were acquired for comparison. Image texture measures were computed for soft-tissue regions of the plaques. Results: Ultrasound evaluation identified plaques as homogeneous without calcifications. MIR images revealed complex heterogeneous structure with multiple microcalcifications consistent with histology, and possessed more image texture in specific regions than conventional radiographs (P <.05). MIR refraction images allowed imaging of the geometric structure of tissue interfaces within the plaques, while scatter images contained more texture in soft-tissue regions than absorption or refraction images. Conclusions: X-ray PC imaging better depicts plaque soft-tissue heterogeneity than ultrasound or conventional radiographs. MIR imaging technique should be investigated further as a viable imaging technique to identify high-risk plaques. ? 2012 Elsevier Inc. All rights reserved. |
URI: | http://www.scopus.com/inward/record.url?eid=2-s2.0-84868536560&partnerID=MN8TOARS http://scholars.lib.ntu.edu.tw/handle/123456789/370386 |
DOI: | 10.1016/j.amjsurg.2012.07.021 | SDG/Keyword: | article; carotid artery disease; contrast radiography; controlled study; human; image processing; image quality; imaging and display; intermethod comparison; multiple image radiography; priority journal; soft tissue; synchrotron radiation; Carotid Stenosis; Humans; Plaque, Atherosclerotic; Tomography, X-Ray Computed |
Appears in Collections: | 生物機電工程學系 |
Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.